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dc.date.accessioned2017-10-16T11:25:42Z
dc.date.available2017-10-16T11:25:42Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10852/58824
dc.description.abstractThe purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy children between 4 and 11 years scanned twice, we used tract-based spatial statistics as well as delineation of 15 major WM tracts to characterize the regional pattern of change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD). We tested whether there were decelerations of change with increasing age globally and tract-wise, and also illustrated change along medial-to-lateral, posterior-to-anterior and inferior-to-superior gradients. We found a significant linear increase in global FA, and decrease in MD and RD over time. For mean AD, a weak decrease was observed. The developmental changes in specific WM tracts showed regional differences. Eight WM tracts showed non-linear development patterns for one or several DTI metrics, with a deceleration in change with age. Sex did not affect change in any DTI metric. Overall, greater rate of change was found in the left hemisphere. Spatially, there was a posterior-to-anterior gradient of change with greater change in frontal regions for all metrics. The current study provides a comprehensive characterization of the regional patters of change in WM microstructure across pre-adolescence childhood.en_US
dc.language.isoenen_US
dc.relation.ispartofKrogsrud, Stine Kleppe (2015) Brain development - Hippocampal subfields, microstructural white matter and relation to working memory. Doctoral thesis. http://hdl.handle.net/10852/58825
dc.relation.urihttp://hdl.handle.net/10852/58825
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleChanges in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of ageen_US
dc.typeJournal articleen_US
dc.creator.authorKrogsrud, Stine K.
dc.creator.authorFjell, Anders M.
dc.creator.authorTamnes, Christian K.
dc.creator.authorGrydeland, Håkon
dc.creator.authorMork, Lia
dc.creator.authorDue-Tønnessen, Paulina
dc.creator.authorBjørnerud, Atle
dc.creator.authorSampaio-Baptista, Cassandra
dc.creator.authorAndersson, Jesper
dc.creator.authorJohansen-Berg, Heidi
dc.creator.authorWalhovd, Kristine B.
dc.identifier.jtitleNeuroImage
dc.identifier.volume124
dc.identifier.issuePart A
dc.identifier.startpage473
dc.identifier.endpage486
dc.identifier.doihttps://doi.org/10.1016/j.neuroimage.2015.09.017
dc.identifier.urnURN:NBN:no-61548
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/58824/1/1-s2.0-S1053811915008149-main.pdf
dc.type.versionPublishedVersion


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