Hide metadata

dc.date.accessioned2017-09-23T16:46:36Z
dc.date.available2017-09-23T16:46:36Z
dc.date.created2016-06-17T10:45:28Z
dc.date.issued2016
dc.identifier.citationAdamczak, Malgorzata Iwona Martinsen, Ørjan Grøttem Smistad, Gro Hiorth, Marianne . Water sorption properties of HM-pectin and liposomes intended to alleviate dry mouth. Internation Journal of Pharmaceutics. 2016, 506(1-2), 201-206
dc.identifier.urihttp://hdl.handle.net/10852/58496
dc.description.abstractPharmaceutical formulations intended for treatment of xerostomia (dry mouth) should be able to keep the oral mucosa hydrated for a prolonged period of time. The products already existing on the market contain water-soluble polymers, however their ability to moisturize the oral mucosa for a longer period of time seems limited. In this paper the sorption properties of water vapor of high-methoxylated pectin (HM-pectin, a hydrophilic biopolymer) and phosphatidylcholine-based (Soya-PC) liposomes have been studied and compared using a gravimetric method. The kinetics of water desorption and sorption have been recorded over the relative humidity range RH = 95–0–95%, at 35 °C. The obtained isotherms were found to be well described by the n-layer Brunauer-Emmet-Teller (BET) adsorption model. The water isotherms on HM-pectin were Type II (IUPAC), while water isotherms on liposomes were Type III. The maximum water sorption capacity of liposomes (1.2 mg water per mg of adsorbent at 95% RH) was found to be twice as high as for pectin. Due to the slower water release from the liposomes, as well as their high water sorption capacity, they seem to have great potential in relieving the symptoms of dry mouth syndrome.en_US
dc.languageEN
dc.publisherElsevier Science
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleWater sorption properties of HM-pectin and liposomes intended to alleviate dry mouthen_US
dc.typeJournal articleen_US
dc.creator.authorAdamczak, Malgorzata Iwona
dc.creator.authorMartinsen, Ørjan Grøttem
dc.creator.authorSmistad, Gro
dc.creator.authorHiorth, Marianne
cristin.unitcode185,15,23,10
cristin.unitnameFarmasi
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1362137
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Internation Journal of Pharmaceutics&rft.volume=506&rft.spage=201&rft.date=2016
dc.identifier.jtitleInternation Journal of Pharmaceutics
dc.identifier.volume506
dc.identifier.issue1-2
dc.identifier.startpage201
dc.identifier.endpage206
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2016.04.050
dc.identifier.urnURN:NBN:no-61188
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0378-5173
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/58496/2/REV_water%2Bsorption%2Bproperties_%2BDVS1.pdf
dc.type.versionAcceptedVersion


Files in this item

Appears in the following Collection

Hide metadata

Attribution-NonCommercial-NoDerivs 3.0 Unported
This item's license is: Attribution-NonCommercial-NoDerivs 3.0 Unported