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dc.date.accessioned2017-09-23T16:37:44Z
dc.date.available2018-05-15T22:31:37Z
dc.date.created2017-06-01T10:03:18Z
dc.date.issued2017
dc.identifier.citationAdamczak, Malgorzata Iwona Martinsen, Ørjan Grøttem Smistad, Gro Hiorth, Marianne . Polymer coated mucoadhesive liposomes intended for the management of xerostomia. Internation Journal of Pharmaceutics. 2017, 527(1-2), 72-78
dc.identifier.urihttp://hdl.handle.net/10852/58495
dc.description.abstractThe aim of this work was to prepare and test different pharmaceutical formulations in respect of their potential in relieving dry mouth symptom. Since many of the products available on the market provide only temporary relief to the patients, there is need for new formulations able to retain on the oral mucosa. The prolonged moisture protection could be achieved by combining mucoadhesive materials, such as polymers containing hydrogen bonding groups, with vesicles capable of releasing hydration medium from the inner compartment. In this study three different types of liposomes (positively, negatively and neutrally charged) were coated with five different types of polymers: low-methoxylated pectin (LM-pectin), high-methoxylated pectin (HM-pectin), alginate, chitosan and hydrophobically modified ethyl hydroxyethyl cellulose (HM-EHEC). The particle size and the zeta potential of the obtained carriers were tested by measuring dynamic light scattering (DLS) and electrophoretic mobility. Later on, selected positively charged liposomes were deposited on a negatively charged mica surface and depicted by atomic force microscopy (AFM). The water sorption properties of polymers, uncoated liposomes and polymer-coated liposomes were studied by the means of dynamic vapor sorption (DVS). The experiments were performed within the relative humidity range RH = 95–0–95%, at 35 °C. It was found that coating the liposomes with polymers significantly increased the water sorption capacity of the formulations, making them an attractive choice for hydration of the oral mucosa.en_US
dc.languageEN
dc.publisherElsevier Science
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titlePolymer coated mucoadhesive liposomes intended for the management of xerostomiaen_US
dc.typeJournal articleen_US
dc.creator.authorAdamczak, Malgorzata Iwona
dc.creator.authorMartinsen, Ørjan Grøttem
dc.creator.authorSmistad, Gro
dc.creator.authorHiorth, Marianne
cristin.unitcode185,15,23,10
cristin.unitnameFarmasi
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1473407
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Internation Journal of Pharmaceutics&rft.volume=527&rft.spage=72&rft.date=2017
dc.identifier.jtitleInternation Journal of Pharmaceutics
dc.identifier.volume527
dc.identifier.issue1-2
dc.identifier.startpage72
dc.identifier.endpage78
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2017.05.032
dc.identifier.urnURN:NBN:no-61197
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0378-5173
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/58495/2/REV_Polymer%2Bcoated%2Bmucoadhesive%2Bliposomes%2Bfor%2Bthe%2Bmanagement%2Bof%2Bxerostomiafulltextversion.pdf
dc.type.versionAcceptedVersion


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