Although with a series of repercussions, urban expansion represents one of the indicators of economic growth in most parts of Africa; this partly explains why it is widely studied today. The phenomenon is most rapid in the developing world where cities gain millions of residents annually. The Cameroonian urban landscape has over the years witnessed uncontrolled urban growth which extends at the fringes. This includes Bamenda, the primate city of the North West Region of Cameroon where this process has affected farmers’ livelihoods. While research efforts have been directed towards analysing the environmental implications of urban expansion, an important aspect which seemed to have eluded urban geographical literature or remains insufficient in the context of Bamenda, concerns scientific perspectives on the effect of urban expansion on farmers livelihoods. Taking into consideration two key areas – the Mankon-Bafut axis and the Nkwen Bambui axis, this study analyses the trends and effects of urban expansion on farmers’ livelihoods with a view to identifying ways of making the process more beneficial to the farmers. Maps were used to determine the trend of urban expansion between 2000 and 2015. 12 farmers drawn from the target sites were interviewed while 2 focus group discussions and some interviews were conducted with relevant government and local authorities. The content analysis was employed to analyse perceptions on the effects and coping strategies of farmers to urban expansion. Using the livelihoods approach, farmers’ activities, income, assets, family size, farm sizes and type were analysed for the periods before and after urban expansion while a network analysis was used to establish a relationship between urban expansion and farmers’ livelihoods. Between 2000 and 2015, the surface area for farmlands in Bamenda II and Bamenda III reduced from 3540ha to 2100ha and 2943ha to 1389ha respectively. This was followed by a corresponding increase in the surface area for settlements from 2100ha to 3540ha in Bamenda II and from 1389ha to 2943ha in Bamenda III. The expansion process has affected farmers’ income, farm sizes and farming types, natural capital and their standards of living. Most of the farmers have employed coping measures to include the diversification of income opportunities, social networking, agricultural intensification and borrowing among others. Much effort are required to seek permanent solutions to the effects of urban expansion. Future efforts could target land use regulations to stem the uncontrolled rate of settlement expansion, intensive farming to increase productivity and processing to improve value chain in a bid to increase income levels and provide long-term food self-sufficiency.