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dc.date.accessioned2017-08-08T08:50:32Z
dc.date.available2017-08-08T08:50:32Z
dc.date.created2013-09-24T13:07:58Z
dc.date.issued2013
dc.identifier.citationRangroo, Vinita Thrane, Alexander Stanley Plog, Benjamin A. Thiyagarajan, Meenakshisundaram Iliff, Jeffrey J. Deane, Rashid Nagelhus, Erlend Arnulf Nedergaard, Maiken . Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific Reports. 2013, 3:2582
dc.identifier.urihttp://hdl.handle.net/10852/56832
dc.description.abstractIn the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo two-photon imaging we demonstrate that the paravascular circulation facilitates selective transport of small lipophilic molecules, rapid interstitial fluid movement and widespread glial calcium signaling. Depressurizing the paravascular system leads to unselective lipid diffusion, intracellular lipid accumulation and pathological signaling in astrocytes. As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules.en_US
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleParavascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brainen_US
dc.typeJournal articleen_US
dc.creator.authorRangroo, Vinita
dc.creator.authorThrane, Alexander Stanley
dc.creator.authorPlog, Benjamin A.
dc.creator.authorThiyagarajan, Meenakshisundaram
dc.creator.authorIliff, Jeffrey J.
dc.creator.authorDeane, Rashid
dc.creator.authorNagelhus, Erlend Arnulf
dc.creator.authorNedergaard, Maiken
cristin.unitcode185,51,0,0
cristin.unitnameInstitutt for medisinske basalfag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1051722
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=3:2582&rft.spage=&rft.date=2013
dc.identifier.jtitleScientific Reports
dc.identifier.volume3:2582
dc.identifier.doihttp://dx.doi.org/10.1038/srep02582
dc.identifier.urnURN:NBN:no-59661
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/56832/1/srep02582.pdf
dc.type.versionPublishedVersion


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