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dc.date.accessioned2017-08-04T10:20:44Z
dc.date.available2017-08-04T10:20:44Z
dc.date.created2012-12-04T16:41:51Z
dc.date.issued2012
dc.identifier.citationElshorbagy, Amany K Valdivia-Garcia, Maria Refsum, Helga Butte, Nancy . The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents. PLoS ONE. 2012, 7(9)
dc.identifier.urihttp://hdl.handle.net/10852/56770
dc.description.abstractContext: Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in others. Objective: To investigate whether the association of tCys with body fat extends to children at particular risk of obesity, and whether tCys is associated with insulin resistance and obesity-associated inflammation. Methods: We explored the cross-sectional relations of fasting plasma tCys and related metabolites with body composition measured by dual-energy X-ray absorptiometry in 984 Hispanic children and adolescents aged 4–19 years from the Viva La Familia Study. Linear and logistic regression and dose-response curves were used to evaluate relations of tCys with obesity, insulin resistance and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein (CRP). Results: tCys, methionine and total homocysteine (tHcy) increased with age. Upper tCys quartile was independently associated with a 5-fold increased risk of obesity (95% CI 3.5–8.0, P<0.001), and 2-fold risk of insulin resistance (95% CI: 1.6-5.0, P<0.001; adjusted for body fat%). Within the overweight/obese subgroup, but not in normal-weight children, tCys accounted for 9% of the variability in body fat% (partial r = 0.30, P<0.001; adjusted for age and gender). tCys correlated positively with serum non-esterified fatty acids and leptin, partly independent of body fat, but was not associated with serum IL-6, TNF-α or MCP-1. A positive correlation with CRP disappeared after adjustment for BMI. Conclusion: tCys is independently associated with obesity and insulin resistance in Hispanic children and adolescents, highlighting a previously underappreciated link between the sulfur amino acid metabolic pathway and obesity and cardiometabolic risk.en_US
dc.languageEN
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleThe Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescentsen_US
dc.typeJournal articleen_US
dc.creator.authorElshorbagy, Amany K
dc.creator.authorValdivia-Garcia, Maria
dc.creator.authorRefsum, Helga
dc.creator.authorButte, Nancy
cristin.unitcode185,51,13,11
cristin.unitnameErnæringsvitenskap: Molekylær ernæringsbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin968041
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=7&rft.spage=&rft.date=2012
dc.identifier.jtitlePLoS ONE
dc.identifier.volume7
dc.identifier.issue9
dc.identifier.pagecount8
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0044166
dc.identifier.urnURN:NBN:no-59536
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/56770/2/journal.pone.0044166.PDF
dc.type.versionPublishedVersion


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