Background: Acute poisonings with central stimulants is a known cause of mortality and morbidity, being responsible for 6 % of annual drug related deaths in Norway. In Oslo, most acute poisonings are treated at an emergency outpatient clinic, which is the setting of this study with the goal to describe clinical presentations, outcomes and patterns of poisonings with central stimulants. Method: A cross-sectional study. Patients presenting at the Oslo Accident and Emergency Outpatient Clinic (Oslo Legevakt) with acute intentional poisonings with central stimulants were included over a period spanning from October 2013 through March 2016. The cases were categorised according to substance(s) of abuse. Main outcome measures were age, sex, toxic agents, clinical features, treatment and referral. Results: There were 1129 cases of acute poisonings with central stimulants. 861 (76 %) were male, and median age was 30 years. The most frequently used stimulants were amphetamine (65 %), cocaine (21 %) and ecstasy (9 %). The most frequent clinical presentations were tachycardia (43 %), agitation (28 %), anxiety (14 %) and psychosis (13 %). Cocaine users presented most with chest pain (22 %) and anxiety (26 %), while users of uncommon or unknown stimulants had the highest amount of presentations showing agitation (62 %), psychosis (47 %) and hallucinations (24 %). A total of 5 % were given sedating agents. Most patients were discharged or left the clinic on their own, while 9 % were admitted to psychiatric care and 17 % to other hospital departments. There were no recorded deaths. Conclusions: There was seen an increase in poisonings with cocaine, ecstasy and probably also novel psychoactive substances (NPS) according to earlier years. High morbidity was seen in those who had taken stimulants different from the classic ones, with more referrals to hospitals and more presentations of psychosis, hallucinations and agitation.