Objective: The goal of this study was to survey whether or not the national guidelines for antibiotic treatment in hospitals were followed in the emergency department of Akershus University Hospital. Background: Akershus University Hospital has been, and is, working with the implementation of the national guidelines for antibiotic treatment which was released by the Norwegian Directorate of Health in 2013. These were created, amongst other reasons, to fight the development of resistance to antimicrobial treatment, which in modern medicine is a growing concern. Method: The study includes 100 adult patients who have been admitted to the medical emergency department of Akershus University Hospital on Tuesdays between April 7 2015 and June 9 2015. The main criterion for inclusion was the prescription of antibiotic treatment within the emergency department. Information from journals were retrospectively and manually extracted to a database, which created the base for evaluating the choice of antimicrobial treatment, the use of microbiological sampling, as well as whether or not the choice of treatment were explained adequately within the journal. Results: The study has shown that 29 out of the 100 prescriptions did not match the guidelines. The majority of these were caused by prescription of either cefuroxime or cefotaxime. These drugs were prescribed respectively 13 and 7 times where they were not recommended by the guidelines. Microbiological sampling was satisfactory, except for the sputum samples in cases of suspected airway infections. More than 1 in 3 of the admission journals were inadequate in that they did not explain the choice of antibiotic drug. Discussion: The results from the study are at least indicative of an actual systematic misuse of cefuroxime, and perhaps cefotaxime. The main reason is the lack of contraindications towards the use of the standard regimen, as well as the idea that cefuroxime will cover both pneumonia and UTI in cases where the diagnosis is hard to establish.