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dc.contributor.authorYang, Runkuan
dc.contributor.authorZhu, Shengtao
dc.contributor.authorTonnessen, Tor I
dc.date.accessioned2017-01-03T04:33:16Z
dc.date.available2017-01-03T04:33:16Z
dc.date.issued2016
dc.identifier.citationJournal of Inflammation. 2016 Dec 03;13(1):37
dc.identifier.urihttp://hdl.handle.net/10852/53441
dc.description.abstractEthyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). Treatment with EP is able to ameliorate systemic inflammation and multiple organ dysfunctions in multiple animal models, such as acute pancreatitis, alcoholic liver injury, acute respiratory distress syndrome (ARDS), acute viral myocarditis, acute kidney injury and sepsis. Recent studies have demonstrated that prolonged treatment with EP can ameliorate experimental ulcerative colitis and slow multiple tumor growth. It has become evident that EP has pharmacological anti-inflammatory effect to inhibit multiple early inflammatory cytokines and the late inflammatory cytokine HMGB1 release, and the anti-tumor activity is likely associated with its anti-inflammatory effect. EP has been tested in human volunteers and in a clinical trial of patients undergoing cardiac surgery in USA and shown to be safe at clinical relevant doses, even though EP fails to improve outcome of the heart surgery, EP is still a promising agent to treat patients with multiple inflammatory organ injuries and the other clinical trials are on the way. This review focuses on how EP is able to ameliorate multiple organ injuries and summarize recently published EP investigations. Graphical Abstract The targets of the anti-inflammatory agent EP
dc.language.isoeng
dc.rightsThe Author(s).; licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEthyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
dc.typeJournal article
dc.date.updated2017-01-03T04:33:17Z
dc.creator.authorYang, Runkuan
dc.creator.authorZhu, Shengtao
dc.creator.authorTonnessen, Tor I
dc.identifier.doihttp://dx.doi.org/10.1186/s12950-016-0144-1
dc.identifier.urnURN:NBN:no-56649
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/53441/1/12950_2016_Article_144.pdf
dc.type.versionPublishedVersion
cristin.articleid37


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