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dc.date.accessioned2016-12-06T16:40:06Z
dc.date.available2016-12-06T16:40:06Z
dc.date.created2016-11-22T19:11:46Z
dc.date.issued2016
dc.identifier.citationSkonnord, Trygve T. Steen, Finn Skjeie, Holgeir Fetveit, Arne Brekke, Mette Klovning, Atle . Survey Email Scheduling and Monitoring in eRCTs (SESAMe): A Digital Tool to Improve Data Collection in Randomized Controlled Clinical Trials. Journal of Medical Internet Research. 2016, 18(11), e311
dc.identifier.urihttp://hdl.handle.net/10852/53204
dc.description.abstractBackground: Electronic questionnaires can ease data collection in randomized controlled trials (RCTs) in clinical practice. We found no existing software that could automate the sending of emails to participants enrolled into an RCT at different study participant inclusion time points. Objective: Our aim was to develop suitable software to facilitate data collection in an ongoing multicenter RCT of low back pain (the Acuback study). For the Acuback study, we determined that we would need to send a total of 5130 emails to 270 patients recruited at different centers and at 19 different time points. Methods: The first version of the software was tested in a pilot study in November 2013 but was unable to deliver multiuser or Web-based access. We resolved these shortcomings in the next version, which we tested on the Web in February 2014. Our new version was able to schedule and send the required emails in the full-scale Acuback trial that started in March 2014. The system architecture evolved through an iterative, inductive process between the project study leader and the software programmer. The program was tested and updated when errors occurred. To evaluate the development of the software, we used a logbook, a research assistant dialogue, and Acuback trial participant queries. Results: We have developed a Web-based app, Survey Email Scheduling and Monitoring in eRCTs (SESAMe), that monitors responses in electronic surveys and sends reminders by emails or text messages (short message service, SMS) to participants. The overall response rate for the 19 surveys in the Acuback study increased from 76.4% (655/857) before we introduced reminders to 93.11% (1149/1234) after the new function (P<.001). Further development will aim at securing encryption and data storage. Conclusions: The SESAMe software facilitates consecutive patient data collection in RCTs and can be used to increase response rates and quality of research, both in general practice and in other clinical trial settings.en_US
dc.languageEN
dc.language.isoenen_US
dc.rightsAttribution 2.0 Generic
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/
dc.titleSurvey Email Scheduling and Monitoring in eRCTs (SESAMe): A Digital Tool to Improve Data Collection in Randomized Controlled Clinical Trialsen_US
dc.typeJournal articleen_US
dc.creator.authorSkonnord, Trygve T.
dc.creator.authorSteen, Finn
dc.creator.authorSkjeie, Holgeir
dc.creator.authorFetveit, Arne
dc.creator.authorBrekke, Mette
dc.creator.authorKlovning, Atle
cristin.unitcode185,52,15,0
cristin.unitnameAvdeling for allmennmedisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1403101
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Medical Internet Research&rft.volume=18&rft.spage=e311&rft.date=2016
dc.identifier.jtitleJournal of Medical Internet Research
dc.identifier.volume18
dc.identifier.issue11
dc.identifier.doihttp://dx.doi.org/10.2196/jmir.6560
dc.identifier.urnURN:NBN:no-56486
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1438-8871
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/53204/1/Skonnord-JMIR-2016.pdf
dc.type.versionPublishedVersion
cristin.articleide311


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