The following study explored factors affecting acceptance and learning of Virtual Patient Simulation (VPS) in a mental health care context. The use of VPS is increasing in healthcare sector, as it is considered to have educational and cost-effective benefits. To identify which factors that influence acceptance and learning is important for successful organizational and educational implementation. Results from an experiment revealed a significant increase in the belief of technology after testing a Virtual Patient Game and that students were satisfied with the simulation learning outcomes of Reasoning and Reflection of Ability. While there were minor tendencies of experience (Formal Education, work experience and game experience) providing different effect for this satisfaction, none of these were significant. However, Perceived Ease of Use and Perceived Usefulness proved to be influential for the increase of belief in the technology and perceived leaning outcomes. The analysis underlines the importance of pre-perceptions and usability with the implementation of VPS-programs, which should be considered carefully before the training begins.