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dc.date.accessioned2016-05-19T08:25:22Z
dc.date.available2016-05-19T08:25:22Z
dc.date.created2014-06-24T10:19:12Z
dc.date.issued2014
dc.identifier.citationElvemo, Nicolas-Andreas L. Nilsen, Kristian Bernhard Landrø, Nils Inge Borchgrevink, Petter Chr. Håberg, Asta . Patients With chronic pain lack somatic markers during decision-making. Journal of Pain Research. 2014, 7, 425-437
dc.identifier.urihttp://hdl.handle.net/10852/50311
dc.description.abstractPatients with chronic pain have impaired cognitive functions, including decision making, as shown with the Iowa gambling task (IGT). The main aim of this study was to elucidate whether patients' decision making is associated with a lack of the anticipatory skin conductance response (SCR). An increase in anticipatory SCR before making unfavorable choices is known to guide decisions in healthy controls during the IGT. Since several brain regions involved in decision making are reported to have altered morphology in patients with chronic pain, the second aim was to explore the associations between IGT performance and brain structure volumes. Eighteen patients with chronic pain of mixed etiology and 19 healthy controls matched in terms of age, sex, and education were investigated with a computerized IGT during the recording of SCR, heart rate, and blood pressure. The participants also underwent neuropsychological testing, and three-dimensional T1-weighted cerebral magnetic resonance images were obtained. Contrary to controls, patients did not generate anticipatory SCRs before making unfavorable choices, and they switched between decks of cards during the late phase of the IGT significantly more often, and this was still observed after adjusting for depression scores. None of the other autonomic measures differed during IGT performance in either group or between groups. In patients, IGT scores correlated positively with total cortical grey matter volume. In controls, there was no such association, but their IGT scores correlated with the anticipatory SCR. It may be speculated that the reduction in anticipatory SCRs makes the chronic pain patients rely more on cortical resources during decision making.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherDove Medical Press Ltd.
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.titlePatients With chronic pain lack somatic markers during decision-makingen_US
dc.typeJournal articleen_US
dc.creator.authorElvemo, Nicolas-Andreas L.
dc.creator.authorNilsen, Kristian Bernhard
dc.creator.authorLandrø, Nils Inge
dc.creator.authorBorchgrevink, Petter Chr.
dc.creator.authorHåberg, Asta
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1140238
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Pain Research&rft.volume=7&rft.spage=425&rft.date=2014
dc.identifier.jtitleJournal of Pain Research
dc.identifier.volume2014:7
dc.identifier.startpage425
dc.identifier.endpage437
dc.identifier.doihttp://dx.doi.org/10.2147/JPR.S62492
dc.identifier.urnURN:NBN:no-53943
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1178-7090
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/50311/1/JPR-62492-patients-with-chronic-pain-lack-somatic-markers-during-decis_071514.pdf
dc.type.versionPublishedVersion


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