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dc.date.accessioned2016-04-20T12:30:50Z
dc.date.available2016-04-20T12:30:50Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10852/50119
dc.description.abstractObjective Dilated cardiomyopathy (DCM) is characterised by left ventricular dilation and dysfunction not caused by coronary disease, valvular disease or hypertension. Owing to the considerable aetiological and prognostic heterogeneity in DCM, an extensive diagnostic work-up is recommended. We aimed to assess the value of diagnostic testing beyond careful physical examination, blood tests, echocardiography and coronary angiography. Methods From October 2008 to November 2012, we prospectively recruited 102 patients referred to our tertiary care hospital with a diagnosis of ‘idiopathic’ DCM based on patient history, physical examination, routine blood tests, echocardiography and coronary angiography. Extended work-up included cardiac MRI, exercise testing, right-sided catheterisation with biopsies, 24 h ECG and genetic testing. Results In 15 patients (15%), a diagnosis other than ‘idiopathic’ DCM was made based on additional tests. In 10 patients (10%), a possibly disease-causing mutation was detected. 2 patients were found to have non-compaction cardiomyopathy based on MRI findings; 2 patients had systemic inflammatory disease with cardiac involvement; and in 1 patient, cardiac amyloidosis was diagnosed by endomyocardial biopsy. Only in 5 cases did the results of the extended work-up have direct therapeutic consequences. Conclusions In patients with DCM, in whom patient history and routine work-up carry no clues to the aetiology, the diagnostic and therapeutic yield of extensive additional testing is modest.en_US
dc.language.isoenen_US
dc.relation.ispartofBroch, Kaspar (2016) Dilated cardiomyopathy: diagnostic work-up, pathogenesis, prognosis and treatment. Doctoral thesis. http://urn.nb.no/URN:NBN:no-53790
dc.relation.urihttp://urn.nb.no/URN:NBN:no-53790
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleResults of comprehensive diagnostic work-up in ‘idiopathic’ dilated cardiomyopathyen_US
dc.typeJournal articleen_US
dc.creator.authorBroch, Kaspar
dc.creator.authorAndreassen, Arne K.
dc.creator.authorHopp, Einar
dc.creator.authorLeren, Trond Paul
dc.creator.authorScott, Helge
dc.creator.authorMüller, Fredrik
dc.creator.authorAakhus, Svend
dc.creator.authorGullestad, Lars
dc.identifier.jtitleOpen Heart
dc.identifier.doihttp://dx.doi.org/10.1136/openhrt-2015-000271
dc.identifier.urnURN:NBN:no-53785
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/50119/1/Open-Heart-2015-Broch.pdf
dc.type.versionPublishedVersion
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