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dc.date.accessioned2016-02-12T09:50:42Z
dc.date.available2016-02-12T09:50:42Z
dc.date.created2014-05-09T01:35:05Z
dc.date.issued2014
dc.identifier.citationStorsve, Andreas Berg Fjell, Anders Martin Tamnes, Christian Krog Westlye, Lars Tjelta Øverbye, Knut Aasland, Hilde Wiede Walhovd, Kristine B . Differential longitudinal changes in cortical thickness, surface area and volume across the adult lifespan: Regions of accelerating and decelerating change. Journal of Neuroscience. 2014, 34(25), 8488-8498
dc.identifier.urihttp://hdl.handle.net/10852/49161
dc.description.abstractHuman cortical thickness and surface area are genetically independent, emerge through different neurobiological events during development, and are sensitive to different clinical conditions. However, the relationship between changes in the two over time is unknown. Additionally, longitudinal studies have almost invariably been restricted to older adults, precluding the delineation of adult life span trajectories of change in cortical structure. In this longitudinal study, we investigated changes in cortical thickness, surface area, and volume after an average interval of 3.6 years in 207 well screened healthy adults aged 23–87 years. We hypothesized that the relationships among metrics are dynamic across the life span, that the primary contributor to cortical volume reductions in aging is cortical thinning, and that magnitude of change varies with age and region. Changes over time were seen in cortical area (mean annual percentage change [APC], −0.19), thickness (APC, −0.35), and volume (APC, −0.51) in most regions. Volume changes were primarily explained by changes in thickness rather than area. A negative relationship between change in thickness and surface area was found across several regions, where more thinning was associated with less decrease in area, and vice versa. Accelerating changes with increasing age was seen in temporal and occipital cortices. In contrast, decelerating changes were seen in prefrontal and anterior cingulate cortices. In conclusion, a dynamic relationship between cortical thickness and surface area changes exists throughout the adult life span. The mixture of accelerating and decelerating changes further demonstrates the importance of studying these metrics across the entire adult life span.en_US
dc.languageEN
dc.language.isoenen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDifferential longitudinal changes in cortical thickness, surface area and volume across the adult lifespan: Regions of accelerating and decelerating changeen_US
dc.typeJournal articleen_US
dc.creator.authorStorsve, Andreas Berg
dc.creator.authorFjell, Anders Martin
dc.creator.authorTamnes, Christian Krog
dc.creator.authorWestlye, Lars Tjelta
dc.creator.authorØverbye, Knut
dc.creator.authorAasland, Hilde Wiede
dc.creator.authorWalhovd, Kristine B
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1131937
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Neuroscience&rft.volume=34&rft.spage=8488&rft.date=2014
dc.identifier.jtitleJournal of Neuroscience
dc.identifier.volume34
dc.identifier.issue25
dc.identifier.startpage8488
dc.identifier.endpage8498
dc.identifier.doihttp://dx.doi.org/10.1523/JNEUROSCI.0391-14.2014
dc.identifier.urnURN:NBN:no-52939
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0270-6474
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/49161/4/8488.full.pdf
dc.type.versionPublishedVersion


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