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dc.date.accessioned2016-02-08T10:04:38Z
dc.date.available2016-05-19T22:31:02Z
dc.date.created2015-06-25T15:23:45Z
dc.date.issued2015
dc.identifier.citationFjell, Anders Martin Sneve, Markus Handal Storsve, Andreas Berg Grydeland, Håkon Yendiki, Anastasia Walhovd, Kristine B . Brain events underlying episodic memory changes in aging: A longitudinal investigation of structural and functional connectivity. Cerebral Cortex. 2015
dc.identifier.urihttp://hdl.handle.net/10852/48988
dc.description.abstractEpisodic memories are established and maintained by close interplay between hippocampus and other cortical regions, but degradation of a fronto-striatal network has been suggested to be a driving force of memory decline in aging. We wanted to directly address how changes in hippocampal-cortical versus striatal-cortical networks over time impact episodic memory with age. We followed 119 healthy participants (20–83 years) for 3.5 years with repeated tests of episodic verbal memory and magnetic resonance imaging for quantification of functional and structural connectivity and regional brain atrophy. While hippocampal-cortical functional connectivity predicted memory change in young, changes in cortico-striatal functional connectivity were related to change in recall in older adults. Within each age group, effects of functional and structural connectivity were anatomically closely aligned. Interestingly, the relationship between functional connectivity and memory was strongest in the age ranges where the rate of reduction of the relevant brain structure was lowest, implying selective impacts of the different brain events on memory. Together, these findings suggest a partly sequential and partly simultaneous model of brain events underlying cognitive changes in aging, where different functional and structural events are more or less important in various time windows, dismissing a simple uni-factorial view on neurocognitive aging. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The version of record [insert complete citation information here] is available online at: http://dx.doi.org/10.1093/cercor/bhv102en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherOxford University Press
dc.titleBrain events underlying episodic memory changes in aging: A longitudinal investigation of structural and functional connectivityen_US
dc.typeJournal articleen_US
dc.creator.authorFjell, Anders Martin
dc.creator.authorSneve, Markus Handal
dc.creator.authorStorsve, Andreas Berg
dc.creator.authorGrydeland, Håkon
dc.creator.authorYendiki, Anastasia
dc.creator.authorWalhovd, Kristine B
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedfalse
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1250801
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2015
dc.identifier.jtitleCerebral Cortex
dc.identifier.volume26
dc.identifier.issue3
dc.identifier.startpage1272
dc.identifier.endpage1286
dc.identifier.doihttp://dx.doi.org/10.1093/cercor/bhv102
dc.identifier.urnURN:NBN:no-52817
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1047-3211
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/48988/1/Fjell%2Bet%2Bal%2BCerCor%2BFC-memory.pdf
dc.type.versionAcceptedVersion


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