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dc.date.accessioned2016-01-29T15:24:49Z
dc.date.available2016-01-29T15:24:49Z
dc.date.created2016-01-05T13:27:26Z
dc.date.issued2015
dc.identifier.citationReppe, Sjur Wang, Yunpeng Thompson, WK McEvoy, LK Schork, AJ Zuber, Verena LeBlanc, Marissa Bettella, Franscesco Mills, Ian Geoffrey Desikan, Rahul S. Djurovic, Srdjan Gautvik, Kaare M Dale, AM Andreassen, Ole Andreas GEFOS, Consortium . Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci. PLoS ONE. 2015, 10(12), 1-20
dc.identifier.urihttp://hdl.handle.net/10852/48810
dc.description.abstractBone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGenetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Locien_US
dc.typeJournal articleen_US
dc.creator.authorReppe, Sjur
dc.creator.authorWang, Yunpeng
dc.creator.authorThompson, WK
dc.creator.authorMcEvoy, LK
dc.creator.authorSchork, AJ
dc.creator.authorZuber, Verena
dc.creator.authorLeBlanc, Marissa
dc.creator.authorBettella, Franscesco
dc.creator.authorMills, Ian Geoffrey
dc.creator.authorDesikan, Rahul S.
dc.creator.authorDjurovic, Srdjan
dc.creator.authorGautvik, Kaare M
dc.creator.authorDale, AM
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorGEFOS, Consortium
cristin.unitcode185,51,12,30
cristin.unitnameSeksjon for anatomi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1306253
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=10&rft.spage=1&rft.date=2015
dc.identifier.jtitlePLoS ONE
dc.identifier.volume10
dc.identifier.issue12
dc.identifier.startpage1
dc.identifier.endpage20
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0144531
dc.identifier.urnURN:NBN:no-52657
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/48810/1/journal-pone-0144531.pdf
dc.type.versionPublishedVersion
cristin.articleide0144531


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