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dc.date.accessioned2016-01-08T09:50:00Z
dc.date.available2016-01-08T09:50:00Z
dc.date.created2016-01-07T14:21:48Z
dc.date.issued2015
dc.identifier.citationMoshina, Nataliia Ursin, Giske Hoff, Solveig Roth Akslen, Lars A. Roman, Marta Sebuødegård, Sofie Hofvind, Solveig . Mammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Program. Acta Radiologica. 2015
dc.identifier.urihttp://hdl.handle.net/10852/48493
dc.description.abstractBackground High mammographic density might mask breast tumors, resulting in delayed diagnosis or missed cancers. Purpose To investigate the association between mammographic density and histopathologic tumor characteristics (histologic type, size, grade, and lymph node status) among women screened in the Norwegian Breast Cancer Screening Program. Material and Methods Information about 1760 screen-detected ductal carcinoma in situ (DCIS) and 7366 invasive breast cancers diagnosed among women aged 50–69 years, 1996–2010, was analyzed. The screening mammograms were classified subjectively according to the amount of fibroglandular tissue into fatty, medium dense, and dense by breast radiologists. Chi-square test was used to compare the distribution of tumor characteristics by mammographic density. Odds ratio (OR) of tumor characteristics by density was estimated by means of logistic regression, adjusting for screening mode (screen-film and full-field digital mammography), and age. Results Mean and median tumor size of invasive breast cancers was 13.8 and 12 mm, respectively, for women with fatty breasts, and 16.2 and 14 mm for those with dense breasts. Lymph node positive tumors were identified among 20.6% of women with fatty breasts compared with 27.2% of those with dense breasts (P < 0.001). The proportion of DCIS was significantly lower for women with fatty (15.8%) compared with dense breasts (22.0%). Women with dense breasts had an increased risk of large (OR, 1.44; 95% CI, 1.18–1.73) and lymph node positive tumors (OR, 1.26; 95% CI, 1.05–1.51) compared with women with fatty and medium dense breasts. Conclusion High mammographic density was positively associated with tumor size and lymph node positive tumors.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherInforma Healthcare
dc.relation.ispartofMoshina, Nataliia (2017) Understanding the role of mammographic density in a population based breast cancer screening program: A step towards stratified screening for breast cancer in Norway? Doctoral thesis. http://hdl.handle.net/10852/59397
dc.relation.urihttp://hdl.handle.net/10852/59397
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleMammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Programen_US
dc.typeJournal articleen_US
dc.creator.authorMoshina, Nataliia
dc.creator.authorUrsin, Giske
dc.creator.authorHoff, Solveig Roth
dc.creator.authorAkslen, Lars A.
dc.creator.authorRoman, Marta
dc.creator.authorSebuødegård, Sofie
dc.creator.authorHofvind, Solveig
cristin.unitcode185,50,0,0
cristin.unitnameDet medisinske fakultet
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1307943
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta Radiologica&rft.volume=&rft.spage=&rft.date=2015
dc.identifier.jtitleActa Radiologica
dc.identifier.volume4
dc.identifier.issue9
dc.identifier.doihttp://dx.doi.org/10.1177/2058460115604340
dc.identifier.urnURN:NBN:no-52387
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0284-1851
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/48493/1/Acta%2BRadiologica%2BOpen-2015-Moshina-.pdf
dc.type.versionPublishedVersion
cristin.articleid2058460115604340


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