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dc.date.accessioned2015-12-07T12:48:05Z
dc.date.available2015-12-07T12:48:05Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10852/48195
dc.description.abstractObjective We used diffusion tensor imaging (DTI) to test the following hypotheses: (1) there is decreased white matter (WM) integrity in non-demented Parkinson’s disease (PD), (2) WM integrity is differentially reduced in PD and early Alzheimer’s disease (AD) and (3) DTI changes in non-demented PD are specifically associated with cognitive performance. Methods This study included 18 non-demented patients with PD, 18 patients with mild cognitive impairment due to incipient AD and 19 healthy elderly normal control (NC) participants in a cross-sectional design. The participants underwent DTI, and tract-based spatial statistics was used to analyse and extract radial diffusivity and fractional anisotropy. Correlations between scores from a battery of neuropsychological tests and DTI were performed in the PD group. Results Patients with PD had significant differences in DTI in WM underlying the temporal, parietal and occipital cortex as compared with NC. There were no significant differences between the PD and AD groups in the primary region of interest analyses, but compared with NC there was a tendency for more anterior changes in AD in contrast to more posterior changes in PD. In a secondary whole-brain analysis there were frontoparietal areas with significant differences between AD and PD. In patients with PD, there were significant correlations between DTI parameters in WM underlying the prefrontal cortex and executive and visuospatial abilities. Conclusions In early, non-demented PD we found reduced WM integrity underlying the temporal, parietal and occipital cortices. In addition, WM integrity changes in prefrontal areas were associated with executive and visuospatial ability. These findings support that DTI may be an important biomarker in early PD, and that WM changes are related to cognitive impairment in PD.en_US
dc.language.isoenen_US
dc.relation.ispartofAuning, Eirik (2015) Presenting symptoms, biomarkers and underlying brain changes in pre-dementia Lewy body and Alzheimer's disease. Doctoral thesis. http://urn.nb.no/URN:NBN:no-52130
dc.relation.urihttp://urn.nb.no/URN:NBN:no-52130
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleWhite matter integrity and cognition in Parkinson's disease: a cross-sectional studyen_US
dc.typeJournal articleen_US
dc.creator.authorAuning, Eirik
dc.creator.authorKjærvik, Veslemøy Krohn
dc.creator.authorSelnes, Per
dc.creator.authorAarsland, Dag
dc.creator.authorHaram, Astrid
dc.creator.authorBjørnerud, Atle
dc.creator.authorHessen, Erik
dc.creator.authorEsnaashari, Abdolreza
dc.creator.authorFladby, Tormod
dc.identifier.jtitleBMJ Open
dc.identifier.volume4
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2013-003976
dc.identifier.urnURN:NBN:no-52129
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/48195/1/BMJ+Open-2014-Auning-.pdf
dc.type.versionPublishedVersion
cristin.articleide003976


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