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dc.date.accessioned2015-12-01T15:39:54Z
dc.date.available2015-12-01T15:39:54Z
dc.date.created2013-04-17T20:20:49Z
dc.date.issued2013
dc.identifier.citationLøken-Amsrud, Kristin Ingeleiv Myhr, Kjell-Morten Bakke, Søren Jacob Beiske, Antonie Giæver Bjerve, Kristian S Bjørnarå, Bård T. Hovdal, Harald Olav Lilleås, Finn Midgard, Rune Pedersen, Tom Saltyte Benth, Jurate Torkildsen, Øivind Wergeland, Stig Holmøy, Trygve . Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction. PLoS ONE. 2013, 8(1)
dc.identifier.urihttp://hdl.handle.net/10852/48153
dc.description.abstractObjective Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship to disease activity in Norwegian multiple sclerosis (MS) patients. Methods Prospective cohort study in 88 relapsing-remitting MS (RRMS) patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids (the OFAMS study), before and during treatment with interferon beta. The patients were followed for two years with repeated 12 magnetic resonance imaging (MRI) scans and nine serum measurements of alpha-tocopherol. Results During interferon beta (IFNB) treatment, each 10 µmol/L increase in alpha-tocopherol reduced the odds (CI 95%) for simultaneous new T2 lesions by 36.8 (0.5–59.8) %, p = 0.048, and for combined unique activity by 35.4 (1.6–57.7) %, p = 0.042, in a hierarchical regression model. These associations were not significant prior to IFNB treatment, and were not noticeably changed by gender, age, body mass index, HLA-DRB1*15, treatment group, compliance, or the concentrations of 25-hydroxyvitamin D, retinol, neutralising antibodies against IFNB, or the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid. The corresponding odds for having new T1 gadolinium enhancing lesions two months later was reduced by 65.4 (16.5–85.7) %, p = 0.019, and for new T2 lesions by 61.0 (12.4–82.6) %, p = 0.023. Conclusion During treatment with IFNB, increasing serum concentrations of alpha-tocopherol were associated with reduced odds for simultaneous and subsequent MRI disease activity in RRMS patients. © 2013 Løken-Amsrud et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)
dc.titleAlpha-tocopherol and MRI outcomes in multiple sclerosis - association and predictionen_US
dc.typeJournal articleen_US
dc.creator.authorLøken-Amsrud, Kristin Ingeleiv
dc.creator.authorMyhr, Kjell-Morten
dc.creator.authorBakke, Søren Jacob
dc.creator.authorBeiske, Antonie Giæver
dc.creator.authorBjerve, Kristian S
dc.creator.authorBjørnarå, Bård T.
dc.creator.authorHovdal, Harald Olav
dc.creator.authorLilleås, Finn
dc.creator.authorMidgard, Rune
dc.creator.authorPedersen, Tom
dc.creator.authorSaltyte Benth, Jurate
dc.creator.authorTorkildsen, Øivind
dc.creator.authorWergeland, Stig
dc.creator.authorHolmøy, Trygve
cristin.unitcode185,53,30,0
cristin.unitnameKlinikk for indremedisin og laboratoriefag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1024383
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=8&rft.spage=&rft.date=2013
dc.identifier.jtitlePLoS ONE
dc.identifier.volume8
dc.identifier.issue1
dc.identifier.pagecount5
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0054417
dc.identifier.urnURN:NBN:no-52095
dc.subject.nviVDP::Nevrologi: 752
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/48153/2/fetchObject97592.pdf
dc.type.versionPublishedVersion
cristin.articleide54417


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