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dc.contributor.authorRussell, Michael B
dc.date.accessioned2015-11-27T13:03:47Z
dc.date.available2015-11-27T13:03:47Z
dc.date.issued2007
dc.identifier.urihttp://hdl.handle.net/10852/47961
dc.description.abstractThis tutorial describes different methods and results of genetic studies of primary headaches. A positive family history is imprecise, because it does not specify the number of affected, family size or relation to the proband. Nor does it include an interview of the possibly affected family members. Calculation of the familial aggregation after confirmation of the diagnosis by a physician is more precise. Compared to the general population, first-degree relatives of probands with migraine without aura, migraine with aura, chronic tension-type headache and cluster headache has a significantly increased risk of the proband’s disorder. These data are confirmed in twin studies. The primary headaches are caused by a combination of genetic and environmental factors. A major breakthrough was identification of 3 different genes all causing the rare autosomal dominant inherited familial hemiplegic migraine. The genes encode ion channels. So far no genes have been identified to cause the more common types of primary headaches. This is a “Springer Open Choice” article. Unrestricted non-commercial use, distribution, and reproduction in any medium is permitted, provided the original author and source are credited.
dc.language.isoeng
dc.rightsSpringer-Verlag Italia
dc.titleGenetics in primary headaches
dc.typeJournal article
dc.date.updated2015-11-27T13:03:47Z
dc.creator.authorRussell, Michael B
dc.identifier.jtitleThe Journal of Headache and Pain
dc.identifier.volume8
dc.identifier.issue3
dc.identifier.startpage190
dc.identifier.endpage195
dc.identifier.doihttp://dx.doi.org/10.1007/s10194-007-0389-4
dc.identifier.urnURN:NBN:no-51962
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/47961/1/10194_2007_Article_389.pdf
dc.type.versionPublishedVersion


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