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dc.date.accessioned2015-11-17T15:54:07Z
dc.date.available2015-11-17T15:54:07Z
dc.date.created2014-01-10T10:33:27Z
dc.date.issued2013
dc.identifier.citationEriksen, Beate Horsberg Nestaas, Eirik Hole, Torstein Liestøl, Knut Støylen, Asbjørn Fugelseth, Drude . Myocardial function in premature infants: a longitudinal observational study. BMJ Open. 2013, 3(3)
dc.identifier.urihttp://hdl.handle.net/10852/47775
dc.description.abstractObjectives Gestational and chronological age may have an impact on myocardial function. We studied the longitudinal changes of the atrioventricular tissue Doppler velocities in premature infants through the neonatal transitional period and at expected term and explored the reproducibility of the measurements. Design Prospective, observational and longitudinal cohort study. Setting Two-centre study, from a secondary and a tertiary neonatal intensive care unit. Participants 55 infants (29 males) with gestational age 31–35 weeks and birth weight 1127–2836 grams. Primary and secondary outcome measures Pulsed-wave atrioventricular left, septum and right ventricular annulus tissue Doppler systolic (S′), early diastolic (E′) and late diastolic (A′) velocities measured by repeated echocardiographic examinations days 1, 2 and 3 and at expected term. Results All velocities increased significantly from the neonatal period to expected term (p<0.001). We found a significant correlation between gestational age and right-sided S′, E′ and A′ on day 1 (Pearson correlation 0.32–0.46, p<0.05), for S′ in all three walls and septal E′ and A′ on day 2 (Pearson correlation 0.27–0.49, p<0.05). There was a moderate linear correlation between left ventricle end-diastolic length and septal and right S′ at term and for septal E′ and A′ at day 1 (Pearson correlation 0.30–0.56, p<0.05). We found no correlation between heart rate and tissue Doppler velocities when controlling for the effect of fusion. Continuous positive airway pressure showed moderate effect where as persistence of the ductus arteriosus showed no effect on the tissue Doppler velocities. The E′/A′ relationship was consistently reversed throughout the study with frequently fused diastolic tissue velocity signals. Conclusions Pulsed-wave atrioventricular annulus tissue Doppler velocities were related to gestational age, postnatal age and ventricular size. Right ventricle velocities showed more pronounced increase with postnatal maturation than left ventricle velocities. The degree of E′/A′ fusion influenced the diastolic tissue Doppler velocities and should be reported if present.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherBMJ Publishing Group
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleMyocardial function in premature infants: a longitudinal observational studyen_US
dc.typeJournal articleen_US
dc.creator.authorEriksen, Beate Horsberg
dc.creator.authorNestaas, Eirik
dc.creator.authorHole, Torstein
dc.creator.authorLiestøl, Knut
dc.creator.authorStøylen, Asbjørn
dc.creator.authorFugelseth, Drude
cristin.unitcode185,15,5,35
cristin.unitnameForskningsgruppen for biomedisinsk informatikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1087245
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ Open&rft.volume=3&rft.spage=&rft.date=2013
dc.identifier.jtitleBMJ Open
dc.identifier.volume3
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2012-002441
dc.identifier.urnURN:NBN:no-51805
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2044-6055
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/47775/2/e002441.full.pdf
dc.type.versionPublishedVersion
cristin.articleide002441


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