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dc.contributor.authorHofsø, Dag
dc.contributor.authorBirkeland, Kåre I
dc.contributor.authorHolst, Jens J
dc.contributor.authorBollerslev, Jens
dc.contributor.authorSandbu, Rune
dc.contributor.authorRøislien, Jo
dc.contributor.authorHjelmesæth, Jøran
dc.date.accessioned2015-10-20T12:48:25Z
dc.date.available2015-10-20T12:48:25Z
dc.date.issued2015
dc.identifier.citationDiabetology & Metabolic Syndrome. 2015 Aug 22;7(1):69
dc.identifier.urihttp://hdl.handle.net/10852/47419
dc.description.abstractBackground Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown. Results Morbidly obese subjects without known diabetes performed a 75 g oral glucose tolerance test before and after either gastric bypass surgery (n = 64) or an intensive lifestyle intervention programme (n = 55), ClinicalTrials.gov identifier NCT00273104. The age-adjusted effects of the therapeutic procedures and percentage weight change on fasting and 2-h glucose levels at 1 year were explored using multiple linear regression analysis. Mean (SD) serum fasting and 2-h glucose levels at baseline did not differ between the surgery and lifestyle groups. Weight-loss after surgical treatment and lifestyle intervention was 30 (8) and 9 (10) % (p < 0.001). At 1 year, fasting and 2-h glucose levels were significantly lower in the surgery group than in the lifestyle group, 4.7 (0.4) versus 5.4 (0.7) mmol/l and 3.4 (0.8) versus 6.0 (2.4) mmol/l, respectively (both p < 0.001). Gastric bypass and weight-loss had both independent glucose-lowering effects on 2-h glucose levels [B (95 % CI) 1.4 (0.6–2.3) mmol/l and 0.4 (0.1–0.7) mmol/l per 10 % weight-loss, respectively]. Fasting glucose levels were determined by weight change [0.2 (0.1–0.3) mmol/l per 10 % weight-loss] and not by type of treatment. Conclusions Gastric bypass surgery has a clinically relevant glucose-lowering effect on post-challenge glucose levels which is seemingly not mediated through weight-loss alone.
dc.language.isoeng
dc.rightsHofsø et al; licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels
dc.typeJournal article
dc.date.updated2015-10-20T12:48:25Z
dc.creator.authorHofsø, Dag
dc.creator.authorBirkeland, Kåre I
dc.creator.authorHolst, Jens J
dc.creator.authorBollerslev, Jens
dc.creator.authorSandbu, Rune
dc.creator.authorRøislien, Jo
dc.creator.authorHjelmesæth, Jøran
dc.identifier.doihttp://dx.doi.org/10.1186/s13098-015-0066-8
dc.identifier.urnURN:NBN:no-51517
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/47419/1/13098_2015_Article_66.pdf
dc.type.versionPublishedVersion
cristin.articleid69


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