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dc.contributor.authorRødland, Ernst K
dc.contributor.authorUeland, Thor
dc.contributor.authorBjørnsen, Stine
dc.contributor.authorSagen, Ellen L
dc.contributor.authorDahl, Christen P
dc.contributor.authorNaalsund, Anne
dc.contributor.authorMollnes, Tom E
dc.contributor.authorBrosstad, Frank R
dc.contributor.authorMüller, Fredrik
dc.contributor.authorAukrust, Pål
dc.contributor.authorFrøland, Stig S
dc.date.accessioned2015-10-20T10:51:50Z
dc.date.available2015-10-20T10:51:50Z
dc.date.issued2012
dc.identifier.citationBMC Infectious Diseases. 2012 Jun 25;12(1):144
dc.identifier.urihttp://hdl.handle.net/10852/46960
dc.description.abstractBackground The purpose of this study was to investigate mediators of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis (CNPA), a locally, destructive process of the lung due to invasion by Aspergillus species. Methods Measurements of selected biomarkers in 10 patients with CNPA and 19 healthy, matched controls were performed with enzyme-linked immunosorbent assay (ELISA) and multiplex methodology. The gene expressions of relevant biomarkers were analyzed with real-time quantitative RT-PCR. Results Increased concentrations of circulating mediators of inflammation interleukin (IL)-6, IL-8, RANTES, TNF-α, ICAM-1 and mediators involved in endothelial activation and thrombosis (vWF, TF and PAI-1) were observed in patients with CNPA. The concentration of the anti-inflammatory cytokine IL-10 was increased both in plasma and in PBMC in the patient population. The gene expression of CD40L was decreased in PBMC from the patient group, accompanied by decreased concentrations of soluble (s) CD40L in the circulation. Conclusions The proinflammatory response against Aspergillus may be counteracted by reduced CD40L and sCD40L, as well as increased IL-10, which may compromise the immune response against Aspergillus in patients with CNPA.
dc.language.isoeng
dc.rightsRødland et al.; licensee BioMed Central Ltd.
dc.rightsAttribution 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleSystemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis
dc.typeJournal article
dc.date.updated2015-10-20T10:51:50Z
dc.creator.authorRødland, Ernst K
dc.creator.authorUeland, Thor
dc.creator.authorBjørnsen, Stine
dc.creator.authorSagen, Ellen L
dc.creator.authorDahl, Christen P
dc.creator.authorNaalsund, Anne
dc.creator.authorMollnes, Tom E
dc.creator.authorBrosstad, Frank R
dc.creator.authorMüller, Fredrik
dc.creator.authorAukrust, Pål
dc.creator.authorFrøland, Stig S
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-12-144
dc.identifier.urnURN:NBN:no-51123
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/46960/1/12879_2012_Article_1950.pdf
dc.type.versionPublishedVersion
cristin.articleid144


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