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dc.contributor.authorLøvoll, Marie
dc.contributor.authorWiik-Nielsen, Jannicke
dc.contributor.authorGrove, Søren
dc.contributor.authorWiik-Nielsen, Christer R
dc.contributor.authorKristoffersen, Anja B
dc.contributor.authorFaller, Randi
dc.contributor.authorPoppe, Trygve
dc.contributor.authorJung, Joonil
dc.contributor.authorPedamallu, Chandra S
dc.contributor.authorNederbragt, Alexander J
dc.contributor.authorMeyerson, Matthew
dc.contributor.authorRimstad, Espen
dc.contributor.authorTengs, Torstein
dc.date.accessioned2015-10-09T02:12:18Z
dc.date.available2015-10-09T02:12:18Z
dc.date.issued2010
dc.identifier.citationVirology Journal. 2010 Nov 10;7(1):309
dc.identifier.urihttp://hdl.handle.net/10852/46739
dc.description.abstractBackground Cardiomyopathy syndrome (CMS) is a severe disease affecting large farmed Atlantic salmon. Mortality often appears without prior clinical signs, typically shortly prior to slaughter. We recently reported the finding and the complete genomic sequence of a novel piscine reovirus (PRV), which is associated with another cardiac disease in Atlantic salmon; heart and skeletal muscle inflammation (HSMI). In the present work we have studied whether PRV or other infectious agents may be involved in the etiology of CMS. Results Using high throughput sequencing on heart samples from natural outbreaks of CMS and from fish experimentally challenged with material from fish diagnosed with CMS a high number of sequence reads identical to the PRV genome were identified. In addition, a sequence contig from a novel totivirus could also be constructed. Using RT-qPCR, levels of PRV in tissue samples were quantified and the totivirus was detected in all samples tested from CMS fish but not in controls. In situ hybridization supported this pattern indicating a possible association between CMS and the novel piscine totivirus. Conclusions Although causality for CMS in Atlantic salmon could not be proven for either of the two viruses, our results are compatible with a hypothesis where, in the experimental challenge studied, PRV behaves as an opportunist whereas the totivirus might be more directly linked with the development of CMS.
dc.language.isoeng
dc.rightsLøvoll et al; licensee BioMed Central Ltd.
dc.rightsAttribution 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleA novel totivirus and piscine reovirus (PRV) in Atlantic salmon (Salmo salar) with cardiomyopathy syndrome (CMS)
dc.typeJournal article
dc.date.updated2015-10-09T02:12:18Z
dc.creator.authorLøvoll, Marie
dc.creator.authorWiik-Nielsen, Jannicke
dc.creator.authorGrove, Søren
dc.creator.authorWiik-Nielsen, Christer R
dc.creator.authorKristoffersen, Anja B
dc.creator.authorFaller, Randi
dc.creator.authorPoppe, Trygve
dc.creator.authorJung, Joonil
dc.creator.authorPedamallu, Chandra S
dc.creator.authorNederbragt, Alexander J
dc.creator.authorMeyerson, Matthew
dc.creator.authorRimstad, Espen
dc.creator.authorTengs, Torstein
dc.identifier.doihttp://dx.doi.org/10.1186/1743-422X-7-309
dc.identifier.urnURN:NBN:no-50925
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/46739/1/12985_2010_Article_1053.pdf
dc.type.versionPublishedVersion
cristin.articleid309


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