Hide metadata

dc.contributor.authorAamodt Muggerud, Aslaug
dc.contributor.authorJohnsen, Hilde
dc.contributor.authorBarnes, Debra A
dc.contributor.authorSteel, Adam
dc.contributor.authorEystein Lønning, Per
dc.contributor.authorNaume, Bjørn
dc.contributor.authorSørlie, Therese
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.date.accessioned2015-10-09T01:04:38Z
dc.date.available2015-10-09T01:04:38Z
dc.date.issued2006
dc.identifier.citationBMC Cancer. 2006 Mar 15;6(1):59
dc.identifier.urihttp://hdl.handle.net/10852/46392
dc.description.abstractBackground Previously, a total of five breast cancer subtypes have been identified based on variation in gene expression patterns. These expression profiles were also shown to be associated with different prognostic value. In this study tumour samples from 27 breast cancer patients, previously subtyped by expression analysis using DNA microarrays, and four controls from normal breast tissue were included. A new MetriGenix 4D™ array proposed for diagnostic use was evaluated. Methods We applied MetriGenix custom 4D™ arrays for the detection of previously defined molecular subtypes of breast cancer. MetriGenix 4D™ arrays have special features including probe immobilization in microchannels with chemiluminescence detection that enable shorter hybridization time. Results The MetriGenix 4D™ array platform was evaluated with respect to both the accuracy in classifying the samples as well as the performance of the system itself. In a cross validation analysis using "Nearest Shrunken Centroid classifier" and the PAM software, 77% of the samples were classified correctly according to earlier classification results. Conclusion The system shows potential for fast screening; however, improvements are needed.
dc.language.isoeng
dc.rightsMuggerud et al.
dc.rightsAttribution 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleEvaluation of MetriGenix custom 4D™ arrays applied for detection of breast cancer subtypes
dc.typeJournal article
dc.date.updated2015-10-09T01:04:39Z
dc.creator.authorAamodt Muggerud, Aslaug
dc.creator.authorJohnsen, Hilde
dc.creator.authorBarnes, Debra A
dc.creator.authorSteel, Adam
dc.creator.authorEystein Lønning, Per
dc.creator.authorNaume, Bjørn
dc.creator.authorSørlie, Therese
dc.creator.authorBørresen-Dale, Anne-Lise
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2407-6-59
dc.identifier.urnURN:NBN:no-50521
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/46392/1/12885_2005_Article_411.pdf
dc.type.versionPublishedVersion
cristin.articleid59


Files in this item

Appears in the following Collection

Hide metadata

Attribution 2.0 Generic
This item's license is: Attribution 2.0 Generic