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dc.contributor.authorAudun Risøy, Bjørn
dc.contributor.authorRaastad, Truls
dc.contributor.authorHallén, Jostein
dc.contributor.authorLappegård, Knut T
dc.contributor.authorBæverfjord, Kjersti
dc.contributor.authorKravdal, Astrid
dc.contributor.authorMarie Siebke, Else
dc.contributor.authorBenestad, Haakon B
dc.date.accessioned2015-10-09T01:03:18Z
dc.date.available2015-10-09T01:03:18Z
dc.date.issued2003
dc.identifier.citationBMC Physiology. 2003 Dec 11;3(1):14
dc.identifier.urihttp://hdl.handle.net/10852/46324
dc.description.abstractBackground During infections, polymorphonuclear neutrophilic granulocytes (PMN) are mobilized from their bone marrow stores, travel with blood to the affected tissue, and kill invading microbes there. The signal(s) from the inflammatory site to the marrow are unknown, even though a number of humoral factors that can mobilize PMN, are well known. We have employed a standardized, non-infectious human model to elucidate relevant PMN mobilizers. Well-trained athletes performed a 60-min strenuous strength workout of leg muscles. Blood samples were drawn before, during and just after exercise, and then repeatedly during the following day. Cortisol, GH, ACTH, complement factors, high-sensitive CRP (muCRP), IL-6, G-CSF, IL-8 (CXCL8) and MIP-1β (CCL4) were measured in blood samples. PMN chemotaxins in test plasma was assessed with a micropore membrane technique. Results About 5 hr after the workout, blood granulocytosis peaked to about 150% of baseline. Plasma levels of GH increased significantly 30 min into and 5 min after the exercise, but no increase was recorded for the other hormones. No significant correlation was found between concentrations of stress hormones and the subjects' later occurring PMN increases above their individual baselines. Plasma G-CSF increased significantly – but within the normal range – 65 min after the workout. IL-6 increased very slightly within the normal range, and the chemokines IL-8 and MIP-1β did not increase consistently. However, we found a significant increase of hitherto non-identified PMN-chemotactic activity in plasma 35, 50, and 60 min after the exercise. No systemic complement activation was detected, and (mu)CRP was within the reference range at rest, 5 h and 23 h after the exercise. After endurance exercise, similar findings were made, except for a cortisol response, especially from non-elite runners. Conclusion Apparently, a multitude of humoral factors can – directly or indirectly – mobilize PMN from marrow to blood; some of the factors are, others are not known to be, chemotactic. Under different conditions, different selections of these mobilizers may be used. In the late granulocytosis after heavy, long-lasting exercise a number of factors thought capable of mimicking the granulocytosis of infectious diseases were apparently irrelevant. © 2003 Risøy et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
dc.language.isoeng
dc.rightsRisøy et al
dc.titleDelayed leukocytosis after hard strength and endurance exercise: Aspects of regulatory mechanisms
dc.typeJournal article
dc.date.updated2015-10-09T01:03:18Z
dc.creator.authorAudun Risøy, Bjørn
dc.creator.authorRaastad, Truls
dc.creator.authorHallén, Jostein
dc.creator.authorLappegård, Knut T
dc.creator.authorBæverfjord, Kjersti
dc.creator.authorKravdal, Astrid
dc.creator.authorMarie Siebke, Else
dc.creator.authorBenestad, Haakon B
dc.identifier.doihttp://dx.doi.org/10.1186/1472-6793-3-14
dc.identifier.urnURN:NBN:no-50570
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/46324/1/12899_2003_Article_48.pdf
dc.type.versionPublishedVersion
cristin.articleid14


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