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dc.date.accessioned2015-10-06T14:06:01Z
dc.date.available2015-10-06T14:06:01Z
dc.date.created2015-09-28T12:54:56Z
dc.date.issued2015
dc.identifier.citationTapia, German Bøås, Håkon De Muinck, Eric Cinek, Ondrej Stene, Lars Christian Torjesen, Peter A Rasmussen, Trond Rønningen, Kjersti Skjold . Saffold Virus, a Human Cardiovirus, and Risk of Persistent Islet Autoantibodies in the Longitudinal Birth Cohort Study MIDIA. PLoS ONE. 2015, 10(8)
dc.identifier.urihttp://hdl.handle.net/10852/46170
dc.description.abstractThe aim of this study was to describe the frequency and distribution of Saffold virus in longitudinal stool samples from children, and test for association with development of persistent autoantibodies predictive of type 1 diabetes. A cohort of Norwegian children carrying the HLA genotype associated with highest risk of type 1 diabetes (“DR4-DQ8/DR3-DQ2”) was followed with monthly stool samples from 3 to 35 months of age. Blood samples were tested for autoantibodies to insulin, glutamic acid decarboxylase65 and Islet Antigen-2. 2077 stool samples from 27 children with ≥2 repeatedly positive islet autoantibodies (cases), and 53 matched controls were analysed for Saffold virus genomic RNA by semi-quantitative real-time reverse transcriptase PCR. Saffold virus was found in 53 of 2077 (2.6%) samples, with similar proportions between cases (2.5%) and controls (2.6%). The probability of being infected by 3 years of age was 28% (95% CI 0.18–0.40). Viral quantities ranged from <1 to almost 105 copies/μl. Estimated odds ratio between islet autoimmunity and infection episodes prior to seroconversion was 1.98 (95% CI: 0.57–6.91, p = 0.29). Saffold virus had no statistically significant association with islet autoimmunity.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSaffold Virus, a Human Cardiovirus, and Risk of Persistent Islet Autoantibodies in the Longitudinal Birth Cohort Study MIDIAen_US
dc.typeJournal articleen_US
dc.creator.authorTapia, German
dc.creator.authorBøås, Håkon
dc.creator.authorDe Muinck, Eric
dc.creator.authorCinek, Ondrej
dc.creator.authorStene, Lars Christian
dc.creator.authorTorjesen, Peter A
dc.creator.authorRasmussen, Trond
dc.creator.authorRønningen, Kjersti Skjold
cristin.unitcode185,15,29,50
cristin.unitnameCentre for Ecological and Evolutionary Synthesis
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1275996
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=10&rft.spage=&rft.date=2015
dc.identifier.jtitlePLoS ONE
dc.identifier.volume10
dc.identifier.issue8
dc.identifier.pagecount11
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0136849
dc.identifier.urnURN:NBN:no-50363
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/46170/2/Tapia_2015_Saf.pdf
dc.type.versionPublishedVersion
cristin.articleide0136849


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