Background: Malaria is a disease caused by protozoa in the Plasmodium family and causes over 627 000 deaths annually. Annually, between 28 to 71 travellers from Norway to malaria endemic areas were diagnosed with malaria in 2006-2013. Objective: Preliminary reports from 2013 indicated an increase in the number of malaria cases diagnosed at the Department of Infectious Diseases, Ullevål, Oslo University Hospital (OUS) compared with previous years. The aim of this study was to investigate this possible increase in malaria cases and compare these numbers with data from previous years and reported cases to MSIS. Secondly, we wanted to investigate the need of introducing a PCR- based technique in the diagnostics of malaria at OUS. Methods: Malaria cases in the period 2006 to 2013 were identified from the protocols at the laboratory of the Department of Infectious Diseases and the patients' journals. Results: 162 malaria cases were diagnosed at the Department of Infectious diseases in the period 2006-2013. Thirty-seven cases were identified in 2013, which was higher than the average of 18 cases in the period 2006-2012 (p<0,001). The typical malaria patient was a young man of African origin visiting his previous homeland where he was infected with P. falciparum. Conclusion: The number of malaria cases in 2013 was higher than the average number per year in 2006-2012. It is possible that the introduction of PCR diagnostics, which have a higher sensitivity, would increase the diagnostic precision, especially in cases with a low parasitaemia or mixed infections.