Hide metadata

dc.date.accessioned2015-08-27T13:50:05Z
dc.date.available2015-08-27T13:50:05Z
dc.date.created2015-08-07T14:04:02Z
dc.date.issued2015
dc.identifier.citationBorge, Kaja Sverdrup Nord, Silje Van Loo, Peter Lingjærde, Ole Christian Gunnes, Gjermund Alnæs, Grethe I Grenaker Solvang, Hiroko Kato Luders, Torben Kristensen, Vessela N. Børresen-Dale, Anne-Lise Lingaas, Frode . Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN. PLoS ONE. 2015, 10(5)
dc.identifier.urihttp://hdl.handle.net/10852/45214
dc.description.abstractBackground Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs. Results We found a high occurrence of copy number aberrations in canine mammary tumours, losses being more frequent than gains. Increased frequency of aberrations and loss of heterozygosity were positively correlated with increased malignancy in terms of histopathological diagnosis. One of the most highly recurrently amplified regions harbored the MYC gene. PTEN was located to a frequently lost region and also homozygously deleted in five tumours. Thus, deregulation of these genes due to copy number aberrations appears to be an important event in canine mammary tumour development. Other potential contributors to canine mammary tumour pathogenesis are COL9A3, INPP5A, CYP2E1 and RB1. The present study also shows that a more detailed analysis of chromosomal aberrations associated with histopathological parameters may aid in identifying specific genes associated with canine mammary tumour progression. Conclusions The high frequency of copy number aberrations is a prominent feature of canine mammary tumours as seen in other canine and human cancers. Our findings share several features with corresponding studies in human breast tumours and strengthen the dog as a suitable model organism for this disease.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCanine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTENen_US
dc.typeJournal articleen_US
dc.creator.authorBorge, Kaja Sverdrup
dc.creator.authorNord, Silje
dc.creator.authorVan Loo, Peter
dc.creator.authorLingjærde, Ole Christian
dc.creator.authorGunnes, Gjermund
dc.creator.authorAlnæs, Grethe I Grenaker
dc.creator.authorSolvang, Hiroko Kato
dc.creator.authorLuders, Torben
dc.creator.authorKristensen, Vessela N.
dc.creator.authorBørresen-Dale, Anne-Lise
dc.creator.authorLingaas, Frode
cristin.unitcode185,15,5,35
cristin.unitnameForskningsgruppen for biomedisinsk informatikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1256880
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=10&rft.spage=&rft.date=2015
dc.identifier.jtitlePLoS ONE
dc.identifier.volume10
dc.identifier.issue5
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0126371
dc.identifier.urnURN:NBN:no-49457
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/45214/1/journal.pone.0126371.pdf
dc.type.versionPublishedVersion
cristin.articleide0126371


Files in this item

Appears in the following Collection

Hide metadata

Attribution 4.0 International
This item's license is: Attribution 4.0 International