Abstract
8-Substituted purines have been extensively studied as for example anticancer or antiviral drugs. C-C Bond formation at the purine 8-position has been most commonly done via 8-halopurines, e.g. Pd-catalyzed coupling reactions. Meanwhile, direct conversion of purines not substituted at C-8 to 8-alkylpurines seems to be promising but there are few reports in the literature. In this thesis, addition of an allylmetallic reagent to 8-unsustituted purines followed by oxidation of the adduct to form 8-allylated purines will be discussed.