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dc.date.accessioned2015-08-06T09:03:53Z
dc.date.available2015-08-06T09:03:53Z
dc.date.created2015-04-08T12:28:56Z
dc.date.issued2015
dc.identifier.citationFretland, Åsmund Avdem Kazaryan, Airazat M. Bjørnbeth, Bjørn Atle Flatmark, Kjersti Andersen, Marit Helen Tønnessen, Tor Inge Bjørnelv, Gudrun Maria Waaler Fagerland, Morten Kristiansen, Ronny Øyri, Karl Edwin, Bjørn . Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet study): study protocol for a randomized controlled trial. Trials. 2015
dc.identifier.urihttp://hdl.handle.net/10852/44683
dc.description.abstractBackground Laparoscopic liver resection is used in specialized centers all over the world. However, laparoscopic liver resection has never been compared with open liver resection in a prospective, randomized trial. Methods/Design The Oslo-CoMet Study is a randomized trial into laparoscopic versus open liver resection for the surgical management of hepatic colorectal metastases. The primary outcome is 30-day perioperative morbidity. Secondary outcomes include 5-year survival (overall, disease-free and recurrence-free), resection margins, recurrence pattern, postoperative pain, health-related quality of life, and evaluation of the inflammatory response. A cost-utility analysis of replacing open surgery with laparoscopic surgery will also be performed. The study includes all resections for colorectal liver metastases, except formal hemihepatectomies, resections where reconstruction of vessels/bile ducts is necessary and resections that need to be combined with ablation. All patients will participate in an enhanced recovery after surgery program. A biobank of liver and tumor tissue will be established and molecular analysis will be performed. Discussion After 35 months of recruitment, 200 patients have been included in the trial. Molecular and immunology data are being analyzed. Results for primary and secondary outcome measures will be presented following the conclusion of the study (late 2015). The Oslo-CoMet Study will provide the first level 1 evidence on the benefits of laparoscopic liver resection for colorectal liver metastases.en_US
dc.languageEN
dc.language.isoenen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleOpen versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet study): study protocol for a randomized controlled trialen_US
dc.typeJournal articleen_US
dc.creator.authorFretland, Åsmund Avdem
dc.creator.authorKazaryan, Airazat M.
dc.creator.authorBjørnbeth, Bjørn Atle
dc.creator.authorFlatmark, Kjersti
dc.creator.authorAndersen, Marit Helen
dc.creator.authorTønnessen, Tor Inge
dc.creator.authorBjørnelv, Gudrun Maria Waaler
dc.creator.authorFagerland, Morten
dc.creator.authorKristiansen, Ronny
dc.creator.authorØyri, Karl
dc.creator.authorEdwin, Bjørn
cristin.unitcode185,53,11,13
cristin.unitnameGastromedisinsk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1236015
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Trials&rft.volume=&rft.spage=&rft.date=2015
dc.identifier.jtitleTrials
dc.identifier.volume16
dc.identifier.doihttp://dx.doi.org/10.1186/s13063-015-0577-5
dc.identifier.urnURN:NBN:no-48962
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1745-6215
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/44683/1/s13063-015-0577-5.pdf
dc.type.versionPublishedVersion
cristin.articleid73


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