Browsing Kjemisk institutt by Author "Zeppilli, Davide"

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  • Antioxidant Chimeric Molecules: Are Chemical Motifs Additive? The Case of a Selenium-Based Ligand 
    Zeppilli, Davide; Aldinio-Colbachini, Anna; Ribaudo, Giovanni; Tubaro, Cristina; Dalla Tiezza, Marco; Bortoli, Marco; Zagotto, Giuseppe; Orian, Laura (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    We set up an in silico experiment and designed a chimeric compound integrating molecular features from different efficient ROS (Reactive Oxygen Species) scavengers, with the purpose of investigating potential relationships ...
  • Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling 
    Zeppilli, Davide; Ribaudo, Giovanni; Pompermaier, Nicola; Madabeni, Andrea; Bortoli, Marco; Orian, Laura (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents of the extract of Ginkgo biloba, are investigated in silico (level of theory: (SMD)-M06-2X/6-311+ ...
  • Synthesis of Selenium-Based Small Molecules Inspired by CNS-Targeting Psychotropic Drugs and Mediators 
    Ribaudo, Giovanni; Zeppilli, Davide; Ongaro, Alberto; Bortoli, Marco; Zagotto, Giuseppe; Orian, Laura (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Due to its endogenously high oxygen consumption, the central nervous system (CNS) is vulnerable to oxidative stress conditions. Notably, the activity of several CNS-targeting compounds, such as antidepressant and hypnotic ...