Browsing Kjemisk institutt by Author "Zagotto, Giuseppe"

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  • Antioxidant Chimeric Molecules: Are Chemical Motifs Additive? The Case of a Selenium-Based Ligand 
    Zeppilli, Davide; Aldinio-Colbachini, Anna; Ribaudo, Giovanni; Tubaro, Cristina; Dalla Tiezza, Marco; Bortoli, Marco; Zagotto, Giuseppe; Orian, Laura (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    We set up an in silico experiment and designed a chimeric compound integrating molecular features from different efficient ROS (Reactive Oxygen Species) scavengers, with the purpose of investigating potential relationships ...
  • Synthesis of Selenium-Based Small Molecules Inspired by CNS-Targeting Psychotropic Drugs and Mediators 
    Ribaudo, Giovanni; Zeppilli, Davide; Ongaro, Alberto; Bortoli, Marco; Zagotto, Giuseppe; Orian, Laura (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Due to its endogenously high oxygen consumption, the central nervous system (CNS) is vulnerable to oxidative stress conditions. Notably, the activity of several CNS-targeting compounds, such as antidepressant and hypnotic ...