Browsing Kjemisk institutt by Author "Rafique, Waqas"
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Bekker, Roberto Bartholomeus Wilhelmus; Fjellaksel, Richard; Hjornevik, Trine; Nuruddin, Syed; Rafique, Waqas; Hansen, Jørn H; Sundset, Rune; Haraldsen, Ira Hebold; Riss, Patrick (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin‐releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised ...
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Ott, Julian; Spilhaug, Mona M.; Maschauer, Simone; Rafique, Waqas; Jakobsson, Jimmy Erik; Hartvig, Karoline; Hübner, Harald; Gmeiner, Peter; Prante, Olaf; Riss, Patrick (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)The 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide scaffold was studied as a template for 18F-positron emission tomography (18F-PET) radiotracer development emphasizing sensitivity to changes in opioid receptor ...
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Synthesis of fluorine-18 labelled radiotracers and their pre-clinical and clinical characterization Rafique, Waqas (Doctoral thesis / Doktoravhandling, 2018)Positron emission tomography (PET) is one of the most sensitive in vivo imaging techniques available to clinicians and researchers. It helps in understanding the biological interactions and mechanism of various diseases ...