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dc.date.accessioned2015-04-23T15:31:41Z
dc.date.available2015-04-23T15:31:41Z
dc.date.created2014-01-24T08:45:07Z
dc.date.issued2014
dc.identifier.citationBrurberg, Kjetil Gundro Fønhus, Marita Sporstøl Larun, Lillebeth Flottorp, Signe Agnes Malterud, Kirsti . Case definitions for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) - A systematic review. BMJ Open. 2014, 4(2)
dc.identifier.urihttp://hdl.handle.net/10852/43699
dc.description.abstractObjective To identify case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), and explore how the validity of case definitions can be evaluated in the absence of a reference standard. Design Systematic review. Setting International. Participants A literature search, updated as of November 2013, led to the identification of 20 case definitions and inclusion of 38 validation studies. Primary and secondary outcome measure Validation studies were assessed for risk of bias and categorised according to three validation models: (1) independent application of several case definitions on the same population, (2) sequential application of different case definitions on patients diagnosed with CFS/ME with one set of diagnostic criteria or (3) comparison of prevalence estimates from different case definitions applied on different populations. Results A total of 38 studies contributed data of sufficient quality and consistency for evaluation of validity, with CDC-1994/Fukuda as the most frequently applied case definition. No study rigorously assessed the reproducibility or feasibility of case definitions. Validation studies were small with methodological weaknesses and inconsistent results. No empirical data indicated that any case definition specifically identified patients with a neuroimmunological condition. Conclusions Classification of patients according to severity and symptom patterns, aiming to predict prognosis or effectiveness of therapy, seems useful. Development of further case definitions of CFS/ME should be given a low priority. Consistency in research can be achieved by applying diagnostic criteria that have been subjected to systematic evaluation.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherBMJ Publishing Group
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleCase definitions for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) - A systematic reviewen_US
dc.typeJournal articleen_US
dc.creator.authorBrurberg, Kjetil Gundro
dc.creator.authorFønhus, Marita Sporstøl
dc.creator.authorLarun, Lillebeth
dc.creator.authorFlottorp, Signe Agnes
dc.creator.authorMalterud, Kirsti
cristin.unitcode185,52,0,0
cristin.unitnameInstitutt for helse og samfunn
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1098610
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ Open&rft.volume=4&rft.spage=&rft.date=2014
dc.identifier.jtitleBMJ Open
dc.identifier.volume4
dc.identifier.pagecount12
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2013-003973
dc.identifier.urnURN:NBN:no-48052
dc.subject.nviVDP::Human og veterinærmedisinsk fysiologi: 718
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2044-6055
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43699/1/e003973.full.pdf
dc.type.versionPublishedVersion
cristin.articleide003973


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