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dc.date.accessioned2015-04-23T15:22:23Z
dc.date.available2015-04-23T15:22:23Z
dc.date.created2013-09-26T14:36:09Z
dc.date.issued2013
dc.identifier.citationJebsen, Nina Engellau, Jacob Engström, Katarina Bauer, Henrik C. Monge, Odd R Muren, Ludvig Paul Eide, Geir Egil Trovik, Clement Bruland, Øyvind . Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. International Journal of Radiation Oncology, Biology, Physics. 2013, 86(5), 949-955
dc.identifier.urihttp://hdl.handle.net/10852/43697
dc.description.abstractPurpose To study the impact of dose fractionation of adjuvant radiation therapy (RT) on local recurrence (LR) and the relation of LR to radiation fields. Methods and Materials LR rates were analyzed in 462 adult patients with soft tissue sarcoma who underwent surgical excision and adjuvant RT at five Scandinavian sarcoma centers from 1998 to 2009. Medical records were reviewed for dose fractionation parameters and to determine the location of the LR relative to the radiation portals. Results Fifty-five of 462 patients developed a LR (11.9%). Negative prognostic factors included intralesional surgical margin (hazard ratio [HR]: 7.83, 95% confidence interval [CI]: 3.08-20.0), high malignancy grade (HR: 5.82, 95% CI: 1.31-25.8), age at diagnosis (HR per 10 years: 1.27, 95% CI: 1.03-1.56), and malignant peripheral nerve sheath tumor histological subtype (HR: 6.66, 95% CI: 2.56-17.3). RT dose was tailored to margin status. No correlation between RT dose and LR rate was found in multiple Cox regression analysis. The majority (65%) of LRs occurred within the primary RT volume. Conclusions No significant dose–response effect of adjuvant RT was demonstrated. Interestingly, patients given 45-Gy accelerated RT (1.8 Gy twice daily/2.5 weeks) had the best local outcome. A total dose of 50 Gy in 25 fractions seemed adequate following wide margin surgery. The risk of LR was associated with histopathologic subtype, which should be included in the treatment algorithm of adjuvant RT in soft tissue sarcoma.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherElsevier Science
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.titlePatterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wallen_US
dc.typeJournal articleen_US
dc.creator.authorJebsen, Nina
dc.creator.authorEngellau, Jacob
dc.creator.authorEngström, Katarina
dc.creator.authorBauer, Henrik C.
dc.creator.authorMonge, Odd R
dc.creator.authorMuren, Ludvig Paul
dc.creator.authorEide, Geir Egil
dc.creator.authorTrovik, Clement
dc.creator.authorBruland, Øyvind
cristin.unitcode185,53,19,10
cristin.unitnameAvdeling for kreftbehandling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1052705
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Radiation Oncology, Biology, Physics&rft.volume=86&rft.spage=949&rft.date=2013
dc.identifier.jtitleInternational Journal of Radiation Oncology, Biology, Physics
dc.identifier.volume86
dc.identifier.issue5
dc.identifier.startpage949
dc.identifier.endpage955
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijrobp.2013.04.015
dc.identifier.urnURN:NBN:no-48045
dc.subject.nviVDP::Radiologi og bildediagnostikk: 763
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0360-3016
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43697/1/1-s2.0-S0360301613004446-main.pdf
dc.type.versionPublishedVersion


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