Background: Erysipelas is a common bacterial infection of the skin that occasionally requires hospitalization. As the prevalence of antibiotic resistance in Norway is low, national guidelines recommend use of narrow spectrum antibiotics to treat the infection. Research on adherence to these guideline is scarce. The objective of this study was to evaluate antibiotic prescribing practices and factors affecting prescribing at two different hospital departments, and compare the results. Matierial and methods: Eligble patients were adults who recieved antibiotic treatment for erysipelas at either Ullevål Hospital s Department of Infectious Diseases or Lovisenberg Hospital s Medical Department. Data were collected on demographic information, clinical and laboratory markers of inflammation / sepsis, infectious agents, antibiotic resistance, antimicrobial agents and route of administrations, duration of treatment and length of hospital stay. Comparisons were med between the two departments using Chi Square tests and Mann-Whitney test. Results: 305 cases were included: 212 from Lovisenberg Hospital and 93 from Ullevål Hospital. Patients admitted to the Department of Infectious Diseases (Ullevål) had a higher prevalence of SIRS criteria ≥ 3. Microbial agens were identified in 32% of the blood and tissue cultures taken. This result was approximately the same for both departments, with Staphylococcus aureus and streptococci being the most common agents. Adherence to national guidelines on antimicrobial therapy was seen more often at Lovisenberg, while streamlining to standard treatment occured more commonly at Ullevål. In both departments, we found resistance to macrolides and clindamycin to be much higher than the national rate. A large number of different treatment courses and combinations of antimicrobial agents were identified. Conclusions: Moderate compliance to national guidelines was observed at both departments. Non-adherence resulted in more broadspectrum therapy. It seems that active efforts are needed to secure compliance to the antibiotic guidelines. This is important in order to keep the prevalence of antimicrobial resistance in Norway low.