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dc.contributor.authorØiestad, Andrea
dc.date.accessioned2015-03-23T23:01:07Z
dc.date.available2015-03-23T23:01:07Z
dc.date.issued2014
dc.identifier.citationØiestad, Andrea. Larynxcancer -med utgangspunkt i 1616 pasienter behandlet ved Rikshospitalet fra 1983-2010. Master thesis, University of Oslo, 2014
dc.identifier.urihttp://hdl.handle.net/10852/43402
dc.description.abstractAbstract This assignment is based on a retrospective review of data from 1616 patients treated for laryngeal carcinomas at Rikshospitalet, OUS from 1983 to 2010. Our database contains information about gender, age, smoking-habits, time of diagnosis and subsites. Patients were also categorized according to Union of International Cancer Control (UICC) TNM- classification, and American Joint Committee on Cancer (AJCC) definition of early and advanced staged laryngeal cancer. Early stage was defined as stage I + II and advanced stage was defined as stage III + IV. The majority of our cohort (87%) were men. Throughout the period we observed that females represented an increasing part of the cohort. This change is probably due to changes in smoking habits among women. We found a distinct increase in T1a glottic cancers, with a corresponding decrease in T2 glottic cancers. This shift in glottis T-distribution is probably due to several factors, such as changes in people s smoking habits, earlier referral and diagnosis as well as improved endoscopic tools that makes TNM-staging more accurate. Endoscopic laser surgery is the standard treatment for most T1a glottic cancer, and it has been shown to improve functional outcome and laryngeal preservation. Endoscopic laser surgery may be applied in selected cases of T1b and T2 glottic tumours. There is still no international consensus regarding the preferred treatment for advanced stage tumors.nor
dc.description.abstractAbstract This assignment is based on a retrospective review of data from 1616 patients treated for laryngeal carcinomas at Rikshospitalet, OUS from 1983 to 2010. Our database contains information about gender, age, smoking-habits, time of diagnosis and subsites. Patients were also categorized according to Union of International Cancer Control (UICC) TNM- classification, and American Joint Committee on Cancer (AJCC) definition of early and advanced staged laryngeal cancer. Early stage was defined as stage I + II and advanced stage was defined as stage III + IV. The majority of our cohort (87%) were men. Throughout the period we observed that females represented an increasing part of the cohort. This change is probably due to changes in smoking habits among women. We found a distinct increase in T1a glottic cancers, with a corresponding decrease in T2 glottic cancers. This shift in glottis T-distribution is probably due to several factors, such as changes in people s smoking habits, earlier referral and diagnosis as well as improved endoscopic tools that makes TNM-staging more accurate. Endoscopic laser surgery is the standard treatment for most T1a glottic cancer, and it has been shown to improve functional outcome and laryngeal preservation. Endoscopic laser surgery may be applied in selected cases of T1b and T2 glottic tumours. There is still no international consensus regarding the preferred treatment for advanced stage tumors.eng
dc.language.isonor
dc.titleLarynxcancer -med utgangspunkt i 1616 pasienter behandlet ved Rikshospitalet fra 1983-2010nor
dc.titleLaryngeal cancer -based on 1616 patients treated at Oslo University Hospital, Rikshospitalet from 1983-2010eng
dc.typeMaster thesis
dc.date.updated2015-03-23T23:01:07Z
dc.creator.authorØiestad, Andrea
dc.identifier.urnURN:NBN:no-47740
dc.type.documentProsjektoppgave
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43402/1/Larynxcancer.pdf


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