Objective: To study associations between pain, the use of analgesics, reduction in spare time activities and school absence because of pain among 15-16-year-olds in Norway and high school dropout five years later. Background: Most Norwegian 15-16-year-olds report that they have good health, but pain among adolescents is common and identified as an important health problem. The use of over-the-counter analgesics has increased, also among adolescents. High school dropout is a challenge for the society and put young people at risk for later work marginalization and social exclusion. The etiology is multifactorial and dependent of variables like gender, grades, ethnicity and the parents socioeconomic status. The role of pain and its associations with high school dropout have not been studied before. Method: 14063 Norwegian 15-16-year-olds from six different counties completed a questionnaire and were followed up for five years. Logistic regression was used to compute ORs for high school dropout. Results: 15-16-year-olds who reported pain, frequent use of analgesics, experienced reduced spare time activities and had school absence because of pain, had higher odds of high school dropout five years later. Moderate use of over-the counter analgesics implied lower odds of high school dropout. Conclusion: Pain, loss of function related to pain and pain-related school absence during adolescence may affect the ability to complete high school. Frequent use of analgesics may be a separate risk factor for high school dropout, possibly indicating underlying factors which affects high school completion.