Purpose: To give an introduction to the current literature on the subject of MS caregiver quality of life, and what factors that influence this parameter. Method: A selection of the literature was made through a search in PubMed with a combination of the key words health related quality of life , quality of life , multiple sclerosis , caregiver , caregiver burden , spouse and informal caregiver . A total of 31 articles were selected. There was also a search, which resulted in three other, for background information, in addition to a book. Results: Caregiver quality of life is negatively influenced by lack of social support, the pwMS own (poor) quality of life, and cognitive impairment of the pwMS. The trend of the studies also shows that increasing disability, the more time spent on caregiving, poor education and female gender of caregiver results in poor quality of life. Caregiver quality of life is positively influenced by, among others, social support, good household finances, access to MS focused care and time away from the care giving role. Conclusion: Caregiver quality of life is thus affected by many factors. The caregiver possesses a very important role in the care of the MS-patient. The clinician must try to eliminate the risk of caregiver depression and burnout by minimizing the negative, and foster the positive factors.