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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The major virulence factor of enterotoxigenic Escherichia coli is the heat-labile enterotoxin (LT), an AB5 toxin closely related to the cholera toxin. LT consists of six subunits, the catalytically active A-subunit and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C-glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
PSL1a is a lectin from the mushroom Polyporus squamosus that binds to sialylated glycans and glycoconjugates with high specificity and selectivity. In addition to its N-terminal carbohydrate-binding domain, PSL1a possesses ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Immunotherapy is a growing field in cancer research. A privileged tumor-associated antigen that has received much attention is N-glycolyl (NeuGc) GM3. This ganglioside is present in several types of cancer, but is almost ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
An important function of fungal lectins is to protect their host. Marasmius oreades agglutinin (MOA) is toxic to nematodes and exerts its protective effect through protease activity. Its proteolytic function is associated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Chorismate mutase is a well‐known model enzyme, catalyzing the Claisen rearrangement of chorismate to prephenate. Recent high‐resolution crystal structures along the reaction coordinate of this enzyme enabled computational ...