Cancer is one of the leading causes of premature death in the world and its incidence and mortality are rapidly growing worldwide. Despite the biological heterogeneity of cancer, most patients are still treated with generic ...

Late-stage drug attrition and post-market withdrawals attributed to drug-induced liver injury (DILI) has been a prevailing concern for the pharmaceutical industry. The current gaps in preclinical safety assessment impede ...

Nowadays, radionuclides play an important role in oncology, especially in the developing field of targeted radionuclide therapy (TRT). In this master thesis, the focus is to evaluate different radiolabeled targeting molecules ...

Capturing and storing of CO2 can reduce the emissions of CO2 in the atmosphere. However, such facilities may emit amines that can be transformed into the potentially carcinogenic nitramines dimethylnitramine (DMA-NO2), ...

The liver is the main metabolizing organ in the human body, and several in vitro models have been developed to resemble hepatic drug metabolism. However, commonly used in vitro models such as human liver microsomes (HLMs), ...

Potentiometric acid-base titration was introduced to measure pKa values (Brønsted acidity) of protons in Zr_6-based metal-organic frameworks (MOFs), including UiO-type MOFs and MOF-808. The pKa values of three typical types ...

Dissolved natural organic matter (DNOM) is a complex mixture of heterogeneous organic macromolecules that are formed in the environment, mainly by decay of plant and animal remains. All freshwaters contain a certain amount ...

Polymer micelles can be used in pharmaceuticals, detergents, cosmetics and have a potential for drug delivery systems. In many applications of polymeric micelles, there are also surfactant molecules present. Still, it is ...

NiO and ZnO are a pair of p- and n-type wide band gap metal oxide semiconductors that forms a partially soluble system with each other. Due to these properties, they are considered a potential semiconductor pair for the ...

Organoids and organ-on-a-chip (OoC) are human-induced pluripotent stem cell-derived miniaturized organs that recapitulate organ specific functions. They open up a plethora of opportunities to change the way we test drugs, ...

The conversion of methanol to olefins reaction has been tested over synthesized and commercial SAPO-11, where the supplied and synthesized materials inhibit different morphology, surface area, and acid sites density. The ...

A challenge in drug discovery is the identification of the drug target, called drug deconvolution. Additionally, off-target effects are considered as one of the reasons many developed drugs fail in the clinical trials. The ...

In this work a simple model for biological CO₂-fixation by RuBisCO has been studied where the usual C₅-substrate has been replaced by the C₂-carbohydrate glycolaldehyde in its deprotonated form which is the simplest ion ...

Praktisk gjennomføring av kromatografi i videregående skole blir vanligvis gjort ved at elevene får gjennomføre papir- eller tynnsjiktkromatografi. Med økt tilgang på billige gasskromatografer til undervisningsformål bør ...

A regioselective method for the N3-arylation of hydantoins is investigated. It constitutes an important development complementing classical cyclization strategies. This method involves a Cu-catalyzed boronic acid mediated ...

The increasing demand for faster and more efficient separations for biological samples have driven organic polymer-based monolithic columns back into the spotlight. The nature of the monolithic structure allows the use of ...

Quinolones are a class of synthetic compounds that are used as antibacterial agents since their discovery in the 1960s. Their chemical synthesis has mostly been based on ring-closing reactions, for instance the Gould-Jacobs ...

Abstract A synthetic strategy towards 8-hydroxyphenanthridines (6) was previously developed in our group, where intramolecular Diels-Alder of furan (IMDAF) was the key step. This was a continuation of a previous work as ...

Glioblastoma is the most common and aggressive form of brain cancer. Even with comprehensive treatment regimes, patients face an expected survival of only 15 months. Currently, methods for assessing treatment response are ...

Med den økende forekomsten av multiresistente patogene organismer er det et stort behov for alternativer til de konvensjonelle antimikrobielle medisinene som finnes på markedet i dag. Antimikrobielle peptider (AMPer) er ...

Methods for characterization of additives in decorative type paint are needed to better understand the underlying chemistry. Little information is given by suppliers, and the complexity of paint makes understanding the ...

The availability of many elements is decreasing due to extended use. One possible solution to this problem is the recovery of metals from waste. Fly ash from municipal solid waste (MSW) incineration contains many metals ...

There is a need for comprehensive analysis of the dried blood spot (DBS) metabolome to study both new and known inborn errors of metabolism (IEM). The purpose of this study was to complete and evaluate an untargeted ...

Increasing levels of toxic mecury (Hg) is found in surface waters in boreal parts of Fennoscandia. This is of great concern, as the methylmercury (MeHg) form, can be introduced and accumulate in the aquatic food chain. One ...

Up until now, the antibacterial 8-azaquinolones have been prepared using various ring-closing reactions. This work demonstrates the attempted synthesis of 8-azaquinolone antibacterial agents using a synthetic route that ...

About 5% of solar radiation comes from the ultraviolet (UV) region. It carries high energy and can do serious damage to living organisms. The eye of animals and humans is a critically exposed area and contains UV absorbing ...

Denne oppgaven har hatt flere mål. Det første var å syntetisere AlPO-5 krystaller med varierende lengde samt undersøke effekten synteseparameterne konsentrasjon og aldring av syntese-gel kan ha på morfologi og størrelse. ...

The purpose of this work is to systematically assess the consequences of a potential radiological attack on processed food in a production facility. Infant milk formula (IMF) is specifically chosen as the case of investigation. ...

In this thesis, structural and dynamic features of thermoresponsive amphiphilic pentablock copolymers have been studied for their potential use for drug delivery application. The copolymers are amphiphilic poly(ethylene ...

Biological samples consist of an unknown, but large, number of regulated metabolites. It is of great interest scientifically and clinically to determine the composition and dynamics of this “metabolome”. Metabolomics is ...

Exosomes represent a distinct class of extracellular vesicles of endocytic origin secreted by multiple cell types, including tumour cells. An increased release of exosomes, which appears to be a rich source of biomarkers, ...

We present RP-HPLC methods for the determination of the distribution coefficient at pH 7.4, as log D, and plasma protein binding. Although there are several methods available to determine distribution coefficient (log D) ...

Abstract The use of active pharmaceutical ingredients (APIs) is increasing continuously and thereby constitutes a potential source of surface water contamination. Environmental concentrations of APIs are usually at trace ...

The use of technology in education (so-called e-learning) has seen a rapid development over the last decades. From being small systems that might assist lectures it has developed into systems that could potentially replace ...

Amine-based CO2 capture has been suggested as a way to mitigate global warming. This project aims to improve the understanding of the atmospheric photo-oxidation of two of the simplest imines by OH radicals. Laboratory ...

In this master project, bimetallic nanoparticles with nominal composition Pt1-xPdx NPs (0 ≤ x ≤ 1) have been synthesized via a polyol method. PVP was used as the stabilizer/capping agent, Pt(acac)2 and Pd(acac)2 as metal ...

Forsvarlig bruk av litiumionbatterier krever innsikt og kunnskap om batterienes spesielle egenskaper. Tradisjonelt har man antatt at rask varmeutvikling korresponderer med verste fysiske reaksjon (ventilering, brann, ...

In miniaturized liquid chromatography (LC) an online clean up system and/or pre-concentration step, is essential to increase large loading capacity, loading speed could be used so the analysis is faster, and it is more ...

The main topics of this thesis are the surface kinetics and bulk diffusion of oxygen in Ba(1-x)Gd0.8La(0.2+x)Co2O(6-d) (BGLC). Previous work has identified BGLC as very promising electrode material for SOFC’s and electrolyzers. ...

The cytochrome P450 enzyme, CYP27a1, converts cholesterol into 27-hydroxycholesterol, and both the metabolite and the enzyme are associated with breast cancer, promoting proliferation and metastasis. CYP27A1 is enriched ...

Lakes and rivers are the main sources of drinking water in Nordic countries. For aesthetic and hygienic reasons high concentration levels of dissolved natural organic matter (DNOM) are not acceptable in drinking water. An ...

The structure, thickness and characteristics of liquid chromatography (LC) column materials are central factors regarding their performance. However, miniaturized capillaries (sub 20.0 μm inner diameter, typically used for ...

Liquid chromatography-mass spectrometry (LC-MS) approaches for measurement of biomarkers are increasing in popularity due to the selectivity and sensitivity. To match the detection limits of the immunoassay approaches (such ...

3'-Phosphoadenosine-5'-phosphosulfate (PAPS) is the universal donor of sulfate to sulfotransferases, a large group of enzymes that transfer sulfate to various molecules in the sulfation pathway. Methods that have been ...