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dc.date.accessioned2015-02-03T13:00:29Z
dc.date.available2015-02-03T13:00:29Z
dc.date.created2014-10-01T12:37:18Z
dc.date.issued2014
dc.identifier.citationJenum, Synne Selvam, Sumithra Mahelai, Diana Jesuraj, Nelson Cardenas, Vicky Kenneth, John Hesseling, Anneke C. Doherty, T Mark Vaz, Mario Grewal, Harleen . Influence of Age and Nutritional Status on the Performance of the Tuberculin Skin Test and QuantiFERON®-TB Gold In-Tube in Young Children Evaluated for Tuberculosis in Southern India.. The Pediatric Infectious Disease Journal. 2014
dc.identifier.urihttp://hdl.handle.net/10852/42006
dc.description.abstractBackground: Reliable identification of Mycobacterium tuberculosis infection or tuberculosis (TB) disease in young children is vital to assure adequate preventive and curative treatment. The tuberculin skin test (TST) and IFN[gamma]-release assays may supplement the diagnosis of pediatric TB as cases are typically bacteriologically unconfirmed. However, it is unclear to what extent the performance of TST and QuantiFERON-TB Gold In-Tube (QFT; Cellestis’ IFN[gamma]-release assay test) depends on the demographic, clinical and nutritional characteristics of children in whom they are tested. Methods: During a 2-year prospective observational study of 4382 neonates in Southern India, children with suspected TB were investigated and classified by a standard TB diagnostic algorithm. Results: Clinical TB was diagnosed in 13 of 705 children referred for case verification with suspected TB. TST and QFT had a susceptibility for clinical TB of 31% and 23%, respectively, in this group. Children <2 years were more likely to test QFT indeterminate. A height-for-age Z score within the lowest quartile increased the odds ratio (OR) for a positive or indeterminate QFT result [OR 2.46 (1.19–5.06), OR 3.08 (1.10–8.58)], whereas the OR for a positive TST was reduced with a weight-for-height Z score within the lowest quartile [OR 0.17 (0.06–0.47)]. Conclusion: The sensitivities of the TST and QFT for clinical TB in children <3 years of age were equally poor in this population. Stunted children were more susceptible to Mycobacterium tuberculosis infection and more prone to indeterminate QFT results. TST was less reliable in children with wasting.
dc.languageEN
dc.publisherLippincott Williams &amp; Wilkins
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleInfluence of Age and Nutritional Status on the Performance of the Tuberculin Skin Test and QuantiFERON®-TB Gold In-Tube in Young Children Evaluated for Tuberculosis in Southern India.en_US
dc.typeJournal articleen_US
dc.creator.authorJenum, Synne
dc.creator.authorSelvam, Sumithra
dc.creator.authorMahelai, Diana
dc.creator.authorJesuraj, Nelson
dc.creator.authorCardenas, Vicky
dc.creator.authorKenneth, John
dc.creator.authorHesseling, Anneke C.
dc.creator.authorDoherty, T Mark
dc.creator.authorVaz, Mario
dc.creator.authorGrewal, Harleen
cristin.unitcode185,53,18,13
cristin.unitnameAvdeling for patologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1160432
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The Pediatric Infectious Disease Journal&rft.volume=&rft.spage=&rft.date=2014
dc.identifier.jtitleThe Pediatric Infectious Disease Journal
dc.identifier.volume33
dc.identifier.issue10
dc.identifier.startpagee260
dc.identifier.endpagee269
dc.identifier.doihttp://dx.doi.org/10.1097/INF.0000000000000399
dc.identifier.urnURN:NBN:no-46405
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0891-3668
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/42006/2/Influence_of_Age_and_Nutritional_Status_on_the.8.pdf
dc.type.versionPublishedVersion


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