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dc.date.accessioned2014-09-23T14:43:09Z
dc.date.available2014-09-23T14:43:09Z
dc.date.created2014-09-23T11:25:27Z
dc.date.issued2014
dc.identifier.citationRolin, Johannes Vego, Heidi Maghazachi, Azzam . Oxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytes. Toxins. 2014, 6, 2840-2856
dc.identifier.urihttp://hdl.handle.net/10852/41250
dc.description.abstractLipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed population of human primary monocytes migrated towards LPC, as well as oxidized linoleic acid isoforms 9-S-HODE, 9-R-HODE and 13-R-HODE. Incubation with 9-R-HODE, 13-R-HODE and LPC resulted in increased expression of CXCR4, the receptor for SDF-1a/CXCL12, correlated with increased monocyte migration towards SDF-1a/CXCL12. Further, we report increased expression of CCR9, the receptor for TECK/CCL25, after stimulation with these lipids. Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9. Only LPC but not any other lipid examined increased the influx of intracellular Ca2+ in monocytes. Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses.en_US
dc.languageEN
dc.language.isoenen_US
dc.relation.ispartofRolin, Johannes (2016) Regulation of Human Innate Immune Cells by Inflammatory Lipids. Doctoral thesis. http://urn.nb.no/URN:NBN:no-54107
dc.relation.urihttp://urn.nb.no/URN:NBN:no-54107
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.titleOxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytesen_US
dc.typeJournal articleen_US
dc.creator.authorRolin, Johannes
dc.creator.authorVego, Heidi
dc.creator.authorMaghazachi, Azzam
cristin.unitcode185,51,11,10
cristin.unitnameFysiologi: Inflammasjon
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1156997
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxins&rft.volume=6&rft.spage=2840&rft.date=2014
dc.identifier.jtitleToxins
dc.identifier.volume6
dc.identifier.issue9
dc.identifier.startpage2840
dc.identifier.endpage2856
dc.identifier.doihttp://dx.doi.org/10.3390/toxins6092840
dc.identifier.urnURN:NBN:no-45816
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2072-6651
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/41250/2/Toxins.pdf
dc.type.versionPublishedVersion


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