dc.date.accessioned | 2014-09-23T14:43:09Z | |
dc.date.available | 2014-09-23T14:43:09Z | |
dc.date.created | 2014-09-23T11:25:27Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Rolin, Johannes Vego, Heidi Maghazachi, Azzam . Oxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytes. Toxins. 2014, 6, 2840-2856 | |
dc.identifier.uri | http://hdl.handle.net/10852/41250 | |
dc.description.abstract | Lipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed population of human primary monocytes migrated towards LPC, as well as oxidized linoleic acid isoforms 9-S-HODE, 9-R-HODE and 13-R-HODE. Incubation with 9-R-HODE, 13-R-HODE and LPC resulted in increased expression of CXCR4, the receptor for SDF-1a/CXCL12, correlated with increased monocyte migration towards SDF-1a/CXCL12. Further, we report increased expression of CCR9, the receptor for TECK/CCL25, after stimulation with these lipids. Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9. Only LPC but not any other lipid examined increased the influx of intracellular Ca2+ in monocytes. Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Rolin, Johannes (2016) Regulation of Human Innate Immune Cells by Inflammatory Lipids. Doctoral thesis. http://urn.nb.no/URN:NBN:no-54107 | |
dc.relation.uri | http://urn.nb.no/URN:NBN:no-54107 | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | |
dc.title | Oxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytes | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Rolin, Johannes | |
dc.creator.author | Vego, Heidi | |
dc.creator.author | Maghazachi, Azzam | |
cristin.unitcode | 185,51,11,10 | |
cristin.unitname | Fysiologi: Inflammasjon | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1156997 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxins&rft.volume=6&rft.spage=2840&rft.date=2014 | |
dc.identifier.jtitle | Toxins | |
dc.identifier.volume | 6 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 2840 | |
dc.identifier.endpage | 2856 | |
dc.identifier.doi | http://dx.doi.org/10.3390/toxins6092840 | |
dc.identifier.urn | URN:NBN:no-45816 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2072-6651 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/41250/2/Toxins.pdf | |
dc.type.version | PublishedVersion | |