BACKGROUND AND PURPOSE: Medical brain drain is described as the mass migration of skilled medical workforce from developing countries to developed countries. The subject of medical brain drain has drawn global debate and attention on how to address it. Different policies have been adopted mostly encouraging receiving countries to offer financial assistance to sending countries and recognize ethical recruitment for health workers. The main purpose of this study was to systematically review literature on how medical brain drain has affected health service delivery in Southern and Central Africa METHOD: A comprehensive literature review of articles in English language was carried out, addressing health worker migration or medical brain drain. The following websites were searched; PubMed, Medline, Science Direct, Biomed and Wiley Online Library. The literature search retrieved 1375 references for screening. 378 were considered as potentially eligible studies and were evaluated for full text. 30 studies fulfilled my inclusion criteria which were selected for full text appraisal on the basis that texts suggested policies to combat medical brain drain in Sub-Saharan Africa. Out of the 30 articles included, 24 were empirical studies whereas the other 4 were reports. RESULTS: The study identified a range of factors considered drivers behind health worker migration. These factors were divided into push and pull factors. Among the factors found to be strong push factors and major concerns for the migrated health workers were: low income, poor working environments, lack of career development, political instability, HIV/AIDS and lack of investment in the health system by the governments. Burnout was also reported as a strong push factor due to the much workload against very little manpower to attend to patients. On the other hand high income, global labour market, aging population; career development were reported as the strong pull factors influencing health worker migration. CONCLUSION: The study found that medical brain drain is still on the rise. The findings provide relevance for future research, and should remind both sending and receiving countries and other concerned stakeholders to redesign a balanced solution of policies. Furthermore, instead of solving the problem of brain drain in isolation, this thesis suggests that stakeholders and policy-makers adopt an evidence based policy approach to combat brain drain.