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dc.date.accessioned2014-04-10T11:41:15Z
dc.date.available2014-04-10T11:41:15Z
dc.date.created2014-01-15T23:17:49Z
dc.date.issued2013
dc.identifier.citationWium, Cecilie Aasheim, Erlend T. Ueland, Thor Michelsen, Annika Thorsby, Per Medbøe Larsen, Ingegerd Frøyshov Torjesen, Peter A Aukrust, Pål Birkeland, Kåre I. . Differences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional study. BMC Endocrine Disorders. 2013, 13(49)
dc.identifier.urihttp://hdl.handle.net/10852/39069
dc.description.abstractBackground Immigrants from South Asia to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM). We explored pathogenic factors that might contribute to the high risk of T2DM in Pakistani immigrants to Norway. Methods A cross-sectional study was performed in 18 Pakistani and 21 Norwegian men and women with T2DM (age 29 – 45 years), recruited from two hospital out-patient clinics. Anthropometrics and a two-step euglycemic, hyperinsulinemic clamp with measurements of non-esterified fatty acids (NEFA) during clamp, was performed in all patients. Insulin sensitivity, given as the Glucose Infusion Rate (GIR) and Insulin Sensitivity Index (ISI), was calculated from the two euglycemic clamp steps. Fasting adipokines and inflammatory mediators were measured. Continuous variables between groups were compared using Student’s t test or Mann–Whitney U test as appropriate. Spearman’s correlation coefficient and multiple linear regression analyses were used. Results Despite having a lower BMI, Pakistani patients were more insulin resistant than Norwegian patients, during both low and high insulin infusion rates, after adjustment for sex and % body fat: median (interquartile range) GIR(low insulin): 339.8(468.0) vs 468.4(587.3) µmol/m2/min (p=0.060), ISI(low insulin): 57.1(74.1) vs 79.7(137.9) µmol/m2/min (p=0.012), GIR(high insulin): 1661.1(672.3) vs 2055.6(907.0) µmol/m2/min (p=0.042), ISI(high insulin): 14.2(7.3) vs 20.7(17.2) µmol/m2/min (p=0.014). Pakistani patients had lower percentage NEFA suppression 30 minutes into clamp hyperinsulinemia than Norwegians: 41.9(90.6)% vs 71.2(42.1)%, (p=0.042). The relationship of ISI to BMI, leptin and interleukin-1 receptor antagonist also differed between Norwegians and Pakistanis. Conclusions Compared with Norwegian patients, Pakistani patients with T2DM had lower insulin sensitivity, affecting both glucose and lipid metabolism. The relation of insulin sensitivity to BMI and some adipokines also differed between the groups. Keywords: Ethnicity; South Asian; Insulin sensitivity; Anthropometry; NEFA; Adipokines; Inflammationen
dc.languageEN
dc.language.isoenen_US
dc.publisherBioMed Central
dc.rightsAttribution 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleDifferences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional studyen_US
dc.typeJournal articleen_US
dc.creator.authorWium, Cecilie
dc.creator.authorAasheim, Erlend T.
dc.creator.authorUeland, Thor
dc.creator.authorMichelsen, Annika
dc.creator.authorThorsby, Per Medbøe
dc.creator.authorLarsen, Ingegerd Frøyshov
dc.creator.authorTorjesen, Peter A
dc.creator.authorAukrust, Pål
dc.creator.authorBirkeland, Kåre I.
cristin.unitcode185,53,11,16
cristin.unitnameAvdeling for endokrinologi, sykelig overvekt og forebyggende medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1091415
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC Endocrine Disorders&rft.volume=13&rft.spage=&rft.date=2013
dc.identifier.jtitleBMC Endocrine Disorders
dc.identifier.volume13
dc.identifier.doihttp://dx.doi.org/10.1186/1472-6823-13-49
dc.identifier.urnURN:NBN:no-43876
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1472-6823
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/39069/1/Wium+et+al.pdf
dc.type.versionPublishedVersion
cristin.articleid49


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