New Non-invasive Methods for Quantification of Regional and Global Myocardial Function in the Normal and Ischemic Left Ventricle
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AbstractOptimal handling strategies for patients with suspected or established cardiac disease require non-invasive methods for assessment of the extent and mechanism of LV dysfunction. Although current volumetric and wall motion indices by echocardiography, cardiac MRI or MDCT are useful, additional quantitative and sensitive methods for assessment of myocardial mechanics are needed. Functional analysis is of particular importance in the setting of myocardial ischemia, the most common cause of LV dysfunction. In the present Thesis we introduce and validate LV rotation and strain by STE, and radial strain mapping by multimodality tissue tracking MDCT, as new non-invasive methods for quantitative assessment of the magnitude and timing of regional and global LV deformation. By detailed analysis of regional strain and rotation in the infarcted LV, we demonstrate how ischemic and non-ischemic myocardium affects regional and global deformation indices and how these novel methods can be applied in a clinical setting.
List of papers. The papers are removed from the thesis due to publisher restrictions.
Paper I: Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JA, Torp H, Ihlen H, Smiseth OA. New Noninvasive Method for Assessment of Left Ventricular Rotation: Speckle Tracking Echocardiography. Circulation. 2005; 112; 3149-3156. doi:10.1161/CIRCULATIONAHA.104.531558
Paper II: Helle-Valle T, Remme EW, Lyseggen E, Pettersen E, Vartdal T, Opdahl A, Smith HJ, Osman N, Ihlen H, Edvardsen T, Smiseth OA. Clinical Assessment of Left Ventricular Rotation and Strain – A Novel Approach for Quantification of Function in Infarcted Myocardium and its Border Zones. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H257-67 doi:10.1152/ajpheart.01116.2008
Paper III: Helle-Valle T; Yu WC; Fernandes VRF; Rosen BD; Lima JAC. Usefulness of Radial Strain Mapping by Multidetector Computer Tomography (MDCT) to Quantify Regional Myocardial Function in Patients with Healed Myocardial Infarction. Am J Cardiol. 2010 Aug 15;106(4):483-91. doi:10.1016/j.amjcard.2010.03.063