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Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.

Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid; Steen, Vidar Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)

Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug ...

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)

Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a ...

The impact of immigration and visible minority status on psychosis symptom profile

Berg, Akiah Ottesen; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Romm, Kristin Lie; Hauff, Edvard; Melle, Ingrid (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)

Purpose Immigrants have heightened risks of psychotic disorders, and it is proposed that migration influences symptom profiles. The purpose of this study was to investigate if either migration experience and/or visible ...

Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder

Berg, Akiah Ottesen; Aas, Monica; Larsson, Sara; Nerhus, Mari; Hauff, Edvard; Andreassen, Ole Andreas; Melle, Ingrid (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)

Background Ethnic minority status and childhood trauma are established risk factors for psychotic disorders. Both are found to be associated with increased level of positive symptoms, in particular auditory hallucinations. ...

MicroRNAs enrichment in GWAS of complex human phenotypes

Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, AJ; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)

Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ...

The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Thompson, Paul M; Stein, Jason L; Medland, Sarah E; Hibar, Derrek P; Vasquez, Alejandro Arias; Renteria, Miguel E; Toro, Roberto; Jahanshad, Neda; Schumann, Gunter; Franke, Barbara; Wright, Margaret J; Martin, Nicholas G; Agartz, Ingrid; Alda, Martin; Alhusaini, Saud; Almasy, Laura; Almeida, Jorge; Alpert, Kathryn; Andreasen, Nancy C; Andreassen, Ole Andreas; Apostolova, Liana G; Appel, Katja; Armstrong, Nicola J; Aribisala, Benjamin; Bastin, Mark E; Bauer, Michael; Bearden, Carrie E; Bergmann, Ørjan; Binder, Elisabeth B; Blangero, John; Bockholt, Henry J; Bøen, Erlend; Bois, Catherine; Boomsma, Dorret I; Booth, Tom; Bowman, Ian J; Bralten, Janita; Brouwer, Rachel M; Brunner, Han G; Brohawn, David G; Buckner, Randy L; Buitelaar, Jan; Bulayeva, Kazima; Bustillo, Juan R; Calhoun, Vince D; Cannon, Dara M; Cantor, Rita M; Carless, Melanie A; Caseras, Xavier; Cavalleri, Gianpiero L; Chakravarty, M Mallar; Chang, Kiki D; Ching, Christopher RK; Christoforou, Andrea; Cichon, Sven; Clark, Vincent P; Conrod, Patricia; Coppola, Giovanni; Crespo-Facorro, Benedicto; Curran, Joanne E; Czisch, Michael; Deary, Ian J; de Geus, Eco JC; den Braber, Anouk; Delvecchio, Giuseppe; Depondt, Chantal; de Haan, Lieuwe; de Zubicaray, Greig I; Dima, Danai; Dimitrova, Rali; Djurovic, Srdjan; Dong, Hongwei; Donohoe, Gary; Duggirala, Ravindranath; Dyer, Thomas D; Ehrlich, Stefan; Ekman, Carl Johan; Elvsåshagen, Torbjørn; Emsell, Louise; Erk, Susanne; Espeseth, Thomas; Fagerness, Jesen; Fears, Scott; Fedko, Iryna; Fernandez, Guillen; Fisher, Simon E; Foroud, Tatiana; Fox, Peter T; Francks, Clyde; Frangou, Sophia; Frey, Eva Maria; Frodl, Thomas; Frouin, Vincent; Garavan, Hugh; Giddaluru, Sudheer; Glahn, David C; Godlewska, Beata; Goldstein, Rita Z; Gollub, Randy L; Grabe, Hans J; Grimm, Oliver; Gruber, Oliver; Guadalupe, Tulio; Gur, Raquel E; Gur, Ruben C; Göring, Harald HH; Hagenaars, Saskia; Hajek, Tomas; Hall, Geoffrey B; Hall, Jeremy; Hardy, John; Hartman, Catharina A; Hass, Johanna; Hatton, Sean N; Haukvik, Unn Kristin H.; Hegenscheid, Katrin; Heinz, Andreas; Hickie, Ian B; Ho, Beng-Choon; Hoehn, David; Hoekstra, Pieter J; Hollinshead, Marisa; Holmes, Avram J; Homuth, Georg; Hoogman, Martine; Hong, LElliot; Hosten, Norbert; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E; Hwang, Kristy S; Jack Jr, Clifford R; Jenkinson, Mark; Johnston, Caroline; Jönsson, Erik Gunnar; Kahn, Rene S; Kasperaviciute, Dalia; Kelly, Sinead; Kim, Sungeun; Kochunov, Peter; Koenders, Laura; Krämer, Bernd; Kwok, John BJ; Lagopoulos, Jim; Laje, Gonzalo; Landen, Mikael; Landman, Bennett A; Lauriello, John; Lawrie, Stephen M; Lee, Phil H; Le Hellard, Stephanie; Lemaitre, Herve; Leonardo, Cassandra D; Li, Chiang-shan; Liberg, Benny; Liewald, David C; Liu, Xinmin; Lopez, Lorna M; Loth, Eva; Lourdusamy, Anbarasu; Luciano, Michelle; Macciardi, Fabio; Machielsen, Marise WJ; MacQueen, Glenda M; Malt, Ulrik Fredrik; Mandl, Rene; Manoach, Dara S; Martinot, Jean-Luc; Matarin, Mar; Mather, Karen A; Mattheisen, Manuel; Mattingsdal, Morten; Meyer-Lindenberg, Andreas; McDonald, Colm; McIntosh, Andrew M; McMahon, Francis J; McMahon, Katie L; Meisenzahl, Eva; Melle, Ingrid; Milaneschi, Yuri; Mohnke, Sebastian; Montgomery, Grant W; Morris, Derek W; Moses, Eric K; Mueller, Bryon A; Munoz Maniega, Susana; Muhleisen, Thomas W; Muller-Myhsok, Bertram; Mwangi, Benson; Nauck, Matthias; Nho, Kwangsik; Nichols, Thomas E; Nilsson, Lars-Göran; Nugent, Allison C; Nyberg, Lars; Olvera, Rene L; Oosterlaan, Jaap; Ophoff, Roel A; Pandolfo, Massimo; Papalampropoulou-Tsiridou, Melina; Papmeyer, Martina; Paus, Tomas; Pausova, Zdenka; Pearlson, Godfrey D; Penninx, Brenda W; Peterson, Charles P; Pfennig, Andrea; Phillips, Mary; Pike, GBruce; Poline, Jean-Baptiste; Potkin, Steven G; Putz, Benno; Ramasamy, Adaikalavan; Rasmussen, Jerod; Rietschel, Marcella; Rijpkema, Mark; Risacher, Shannon L; Roffman, Joshua L; Roiz-Santianez, Roberto; Romanczuk-Seiferth, Nina; Rose, Emma J; Royle, Natalie A; Rujescu, Dan; Ryten, Mina; Sachdev, Perminder S; Salami, Alireza; Satterthwaite, Theodore D; Savitz, Jonathan; Saykin, Andrew J; Scanlon, Cathy; Schmaal, Lianne; Schnack, Hugo G; Schork, Andrew J; Schulz, SCharles; Schur, Remmelt; Seidman, Larry; Shen, Li; Shoemaker, Jody M; Simmons, Andrew; Sisodiya, Sanjay M; Smith, Colin; Smoller, Jordan W; Soares, Jair C; Sponheim, Scott R; Sprooten, Emma; Starr, John M; Steen, Vidar Martin; Strakowski, Stephen; Strike, Lachlan; Sussmann, Jessika; Sämann, Philipp G; Teumer, Alexander; Toga, Arthur W; Tordesillas-Gutierrez, Diana; Trabzuni, Daniah; Trost, Sarah; Turner, Jessica; Van den Heuvel, Martijn; van der Wee, Nic J; van Eijk, Kristel; van Erp, Theo GM; van Haren, Neeltje EM; van 't Ent, Dennis; van Tol, Marie-Jose; Valdes Hernandez, Maria C; Veltman, Dick J; Versace, Amelia; Völzke, Henry; Walker, Robert; Walter, Henrik; Wang, Lei; Wardlaw, Joanna M; Weale, Michael E; Weiner, Michael W; Wen, Wei; Westlye, Lars Tjelta; Whalley, Heather C; Whelan, Christopher D; White, Tonya; Winkler, Anderson M; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Zilles, David; Zwiers, Marcel P; Thalamuthu, Anbupalam; Schofield, Peter R; Freimer, Nelson B; Lawrence, Natalia S; Drevets, Wayne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ...

Biological insights from 108 schizophrenia-associated genetic loci

Ripke, Stephan; Neale, B; Corvin, A; Walters, JTR; Farh, KH; Holmans, PA; Lee, P; Bulik-Sullivan, B; Collier, DA; Huang, H; Pers, TH; Agartz, Ingrid; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, SA; Begemann, M; Belliveau, RA; Bene, J; Bergen, SE; Bevilacqua, E; Bigdeli, TB; Black, DW; Bruggeman, R; Buccola, NG; Buckner, RL; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, RM; Carr, VJ; Carrera, N; Catts, SV; Chambert, KD; Chan, RCK; Chen, RYL; Chen, EYH; Cheng, W; Cheung, EFC; Chong, SA; Cloninger, CR; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, JJ; Curtis, D; Davidson, M; Davis, KL; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, Srdjan; Donohoe, G; Drapeau, E; Duan, J; Dudbridge, F; Durmishi, N; Eichhammer, P; Eriksson, J; Escott-Price, V; Essioux, L; Fanous, AH; Farrell, MS; Frank, J; Franke, L; Freedman, R; Freimer, NB; Friedl, M; Friedman, JI; Fromer, M; Genovese, G; Georgieva, L; Giegling, I; Giusti-Rodriguez, P; Godard, S; Goldstein, JI; Golimbet, V; Gopal, S; Gratten, J; De Haan, L; Hammer, C; Hamshere, ML; Hansen, M; Hansen, T; Haroutunian, V; Hartmann, AM; Henskens, FA; Herms, S; Hirschhorn, JN; Hoffmann, P; Hofman, A; Hollegaard, MV; Hougaard, DM; Ikeda, M; Joa, Inge; Julia, A; Kahn, RS; Kalaydjieva, L; Karachanak-Yankova, S; Karjalainen, J; Kavanagh, D; Keller, MC; Kennedy, JL; Khrunin, A; Kim, Y; Klovins, J; Knowles, JA; Konte, B; Kucinskas, V; Kucinskiene, ZA; Kuzelova-Ptackova, H; Kahler, AK; Laurent, C; Keong, JLC; Lee, SH; Legge, SE; Lerer, B; Li, M; Li, T; Liang, KY; Lieberman, J; Limborska, S; Loughland, CM; Lubinski, J; Lonnqvist, J; Macek, M; Magnusson, PKE; Maher, BS; Maier, W; Mallet, J; Marsal, S; Mattheisen, M; Mattingsdal, Morten; McCarley, RW; McDonald, C; McIntosh, AM; Meier, S; Meijer, CJ; Melegh, B; Melle, Ingrid; Mesholam-Gately, RI; Metspalu, A; Michie, PT; Milani, L; Milanova, V; Mokrab, Y; Morris, DW; Mors, O; Murphy, KC; Murray, RM; Myin-Germeys, I; Muller-Myhsok, B; Nelis, M; Nenadic, I; Nertney, DA; Nestadt, G; Nicodemus, KK; Nikitina-Zake, L; Nisenbaum, L; Nordin, A; O'Callaghan, E; O'Dushlaine, C; O'Neill, FA; Oh, SY; Olincy, A; Olsen, L; Van Os, J; Pantelis, C; Papadimitriou, GN; Papiol, S; Parkhomenko, E; Pato, MT; Paunio, T; Pejovic-Milovancevic, M; Perkins, DO; Pietilainen, O; Pimm, J; Pocklington, AJ; Powell, J; Price, A; Pulver, AE; Purcell, SM; Quested, D; Rasmussen, HB; Reichenberg, A; Reimers, MA; Richards, AL; Roffman, JL; Roussos, P; Ruderfer, DM; Salomaa, V; Sanders, AR; Schall, U; Schubert, CR; Schulze, TG; Schwab, SG; Scolnick, EM; Scott, RJ; Seidman, LJ; Shi, J; Sigurdsson, E; Silagadze, T; Silverman, JM; Sim, K; Slominsky, P; Smoller, JW; So, HC; Spencer, CCA; Stahl, EA; Stefansson, H; Steinberg, S; Stogmann, E; Straub, RE; Strengman, E; Strohmaier, J; Stroup, TS; Subramaniam, M; Suvisaari, J; Svrakic, DM; Szatkiewicz, JP; Soderman, E; Thirumalai, S; Toncheva, D; Tosato, S; Veijola, J; Waddington, J; Walsh, D; Wang, D; Wang, Q; Webb, BT; Weiser, M; Wildenauer, DB; Williams, NM; Williams, S; Witt, SH; Wolen, AR; Wong, EHM; Wormley, BK; Xi, HS; Zai, CC; Zheng, X; Zimprich, F; Wray, NR; Stefansson, K; Visscher, PM; Adolfsson, R; Andreassen, Ole Andreas; Blackwood, DHR; Bramon, E; Buxbaum, JD; Børglum, AD; Cichon, S; Darvasi, A; Domenici, E; Ehrenreich, H; Esko, T; Gejman, PV; Gill, M; Gurling, H; Hultman, CM; Iwata, N; Jablensky, AV; Jönsson, Erik Gunnar; Kendler, KS; Kirov, G; Knight, J; Lencz, T; Levinson, DF; Li, QS; Liu, J; Malhotra, AK; McCarroll, SA; McQuillin, A; Moran, JL; Mortensen, PB; Mowry, BJ; Nothen, MM; Ophoff, RA; Owen, MJ; Palotie, A; Pato, CN; Petryshen, TL; Posthuma, D; Rietschel, M; Riley, BP; Rujescu, D; Sham, PC; Sklar, P; St Clair, D; Weinberger, DR; Wendland, JR; Werge, T; Daly, MJ; Sullivan, PF; O'Donovan, MC (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...

Common variant at 16p11.2 conferring risk of psychosis

Steinberg, Stacy; de Jong, S; Mattheisen, M; Costas, J; Demontis, D; Jamain, S; Pietilainen, OPH; Lin, K; Papiol, S; Huttenlocher, J; Sigurdsson, E; Vassos, E; Giegling, I; Breuer, R; Fraser, G; Walker, N; Melle, Ingrid; Djurovic, Srdjan; Agartz, Ingrid; Tuulio-Henriksson, A; Suvisaari, J; Lonnqvist, J; Paunio, T; Olsen, L; Hansen, T; Ingason, A; Pirinen, M; Strengman, E; Hougaard, DM; Orntoft, T; Didriksen, M; Hollegaard, MV; Nordentoft, M; Abramova, L; Kaleda, V; Arrojo, M; Sanjuan, J; Arango, C; Etain, B; Bellivier, F; Meary, A; Schurhoff, F; Szoke, A; Ribolsi, M; Magni, V; Siracusano, A; Sperling, S; Rossner, M; Christiansen, C; Kiemeney, LA; Franke, B; van den Berg, LH; Veldink, J; Curran, S; Bolton, P; Poot, M; Staal, W; Rehnstrom, K; Kilpinen, H; Freitag, CM; Meyer, J; Magnusson, P; Saemundsen, E; Martsenkovsky, I; Bikshaieva, I; Martsenkovska, I; Vashchenko, O; Raleva, M; Paketchieva, K; Stefanovski, B; Durmishi, N; Milovancevic, MP; Tosevski, DL; Silagadze, T; Naneishvili, N; Mikeladze, N; Surguladze, S; Vincent, JB; Farmer, A; Mitchell, PB; Wright, A; Schofield, PR; Fullerton, JM; Montgomery, GW; Martin, NG; Rubino, IA; van Winkel, R; Kenis, G; De Hert, M; Rethelyi, JM; Bitter, I; Terenius, L; Jonsson, EG; Bakker, S; van Os, J; Jablensky, A; Leboyer, M; Bramon, E; Powell, J; Murray, R; Corvin, A; Gill, M; Morris, D; O'Neill, FA; Kendler, K; Riley, B; Craddock, N; Owen, MJ; O'Donovan, MC; Thorsteinsdottir, U; Kong, A; Ehrenreich, H; Carracedo, A; Golimbet, V; Andreassen, Ole Andreas; Borglum, AD; Mors, O; Mortensen, PB; Werge, T; Ophoff, RA; Nothen, MM; Rietschel, M; Cichon, S; Ruggeri, M; Tosato, S; Palotie, A; St Clair, D; Rujescu, D; Collier, DA; Stefansson, H; Stefánsson, Kári (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)

Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 ...

Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: A report from the Cognitive Genomics consorTium (COGENT)

Lencz, T; Knowles, Emily; Davies, G; Guha, S; Liewald, DC; Starr, JM; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; Mukherjee, Sayan; Derosse, P; Lundervold, Arvid; Steen, Vidar Martin; Espeseth, Thomas; John, M.; Räikkönen, K; Widen, E; Palotie, A; Eriksson, JG; Giegling, I; Konte, B; Ikeda, M; Roussos, P; Giakoumaki, S; Burdick, KE; Payton, A.; Ollier, W; Horan, M.; Donohoe, G; Morris, D; Corvin, A; Gill, M; Pendleton, N; Iwata, N; Darvasi, A; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, Stephanie; Keller, MC; Andreassen, Ole Andreas; Deary, IJ; Glahn, DC; Malhotra, AK (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)

It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ...

The role of clusterin in amyloid-β-associated neurodegeneration

Desikan, RS; Thompson, WK; Holland, D; Hess, CP; Brewer, JP; Zetterberg, H; Blennow, K; Andreassen, Ole Andreas; McEvoy, LK; Hyman, BT; Dale, AM (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)

Importance Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well ...

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