Now showing items 3578-3597 of 6063

  • Bindesbøll, Christian; Simonsen, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes ...
  • Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ...
  • Halsne, Ruth (Doctoral thesis / Doktoravhandling, 2011)
  • Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ...
  • Richter, Uwe; Ng, Kah Ying; Suomi, Fumi; Marttinen, Paula; Turunen, Taina; Jackson, Christopher; Suomalainen, Anu; Vihinen, Helena; Jokitalo, Eija; Nyman, Tuula Anneli; Isokallio, Marita A.; Stewart, James B.; Mancini, Cecilia; Brusco, Alfredo; Seneca, Sara; Lombès, Anne; Taylor, Robert W.; Battersby, Brendan J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Mitochondria have a compartmentalized gene expression system dedicated to the synthesis of membrane proteins essential for oxidative phosphorylation. Responsive quality control mechanisms are needed to ensure that aberrant ...
  • Lou, Guofeng; Palikaras, Konstantinos; Hindkjær Lautrup, Sofie; Scheibye-Knudsen, Morten; Tavernarakis, Nektarios; Fang, Evandro Fei (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic ...
  • Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna; Nilsen, Hilde Loge; Bohr, Vilhelm A.; Fang, Evandro Fei (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Mitochondrial dysfunction contributes to normal aging and a wide spectrum of age-related diseases, including neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. It is important to maintain a ...
  • Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S.; Yang, Beimeng; Lautrup, Sofie; Hasan-Olive, Md Mahdi; Caponio, Domenica; Dan, Xiuli; Rocktäschel, Paula; Croteau, Deborah L.; Akbari, Mansour; Greig, Nigel H.; Fladby, Tormod; Nilsen, Hilde; Cader, M. Zameel; Mattson, Mark P.; Tavernarakis, Nektarios; Bohr, Vilhelm A. (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
    Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer’s disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. ...
  • Fykerud, Tone Aase; Knudsen, Lars Mørland; Totland, Max; Sørensen, Vigdis; Dahal-Koirala, Shiva; Lothe, Ragnhild A; Brech, Andreas; Leithe, Edward (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    In order to achieve accurate chromosome segregation, eukaryotic cells undergo a dramatic change in morphology to obtain a spherical shape during mitosis. Interphase cells communicate directly with each other by exchanging ...
  • Dejgaard, Lars; Skjølsvik, Eystein Theodor Ek; Lie, Øyvind Haugen; Ribe, Margareth; Stokke, Mathis Korseberg; Hegbom, Finn; Scheirlynck, Esther S.; Gjertsen, Erik; Andresen, Kristoffer; Helle-Valle, Thomas Michael; Hopp, Einar; Edvardsen, Thor; Haugaa, Kristina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background: Mitral annulus disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD has been associated with mitral valve prolapse (MVP) and sudden cardiac death. Objectives: The ...
  • Dumont, Karl-Andreas; Karlsen, Jørn S; Helle-Valle, Thomas; Fiane, Arnt E; Lundblad, Runar; Urheim, Stig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background We hypothesized that a novel three-dimensional virtual semi-transparent annulus plane (3D VSAP) presented on a holographic screen can be used to visualize the prolapsing tissue in degenerative ...
  • Reiseter, Silje (Doctoral thesis / Doktoravhandling, 2018)
    I sin avhandling «Mixed Connective Tissue Disease – Results from a Nationwide Norwegian Cohort» har lege og forsker Silje Reiseter og medarbeidere studert en gruppe pasienter med bindevevssykdommen Mixed Connective Tissue ...
  • Gunnarsson, Ragnar (Doctoral thesis / Doktoravhandling, 2013)
    The Norwegian mixed connective tissue disease (MCTD) cohort study was the first nationwide study of this rare autoimmune, systemic connective tissue disease (CTD), which was first defined only four decades ago (3).<br> ...
  • Picon, Artzai; Irusta, Unai; Alvarez-Gila, Aitor; Aramendi, Elisabete; Alonso-Atienza, Felipe; Figuera, Carlos; Ayala, Unai; Garrote, Estibaliz; Wik, Lars; Kramer-Johansen, Jo; Eftestøl, Trygve Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Early defibrillation by an automated external defibrillator (AED) is key for the survival of out-of-hospital cardiac arrest (OHCA) patients. ECG feature extraction and machine learning have been successfully used to detect ...
  • Bliksøen, Marte; Rutkovskiy, Arkady; Vaage, John T.; Stensløkken, Kåre-Olav (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Aim: The isolated, retrogradely perfused heart (modified Langendorff model) is a widely used method in experimental heart research. The presence of an intraventricular balloon is necessary to get functional measurements. ...
  • Odden, Sigrun; Landheim, Anne; Clausen, Hanne; Stuen, Hanne K; Heiervang, Kristin S; Ruud, Torleif (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Assertive community treatment (ACT) is an evidence-based treatment for people with severe mental illness, and this model is used widely throughout the world. Given the various adaptations in ...
  • Fraser, Hannah; Martin, Natasha K.; Brummer-Korvenkontio, Henrikki; Carrieri, Patrizia; Dalgard, Olav; Dillon, John; Goldberg, David; Hutchinson, Sharon; Jauffret-Roustide, Marie; Kåberg, Martin; Matser, Amy A.; Matičič, Mojca; Midgard, Håvard; Mravcik, Viktor; Øvrehus, Anne; Prins, Maria; Reimer, Jens; Robaeys, Geert; Schulte, Bernd; van Santen, Daniela Katinka; Zimmermann, Ruth; Vickerman, Peter; Hickman, Matthew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background & Aims Prevention of hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is critical for eliminating HCV in Europe. We estimated the impact of current and scaled-up HCV treatment with ...
  • Lindstrøm, Jonas Christoffer; Dahl, Fredrik Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    A Structural Equations Modeling analysis of multiple groups often involves specification of cross-group parameter equality constraints. In this paper, we present a technique for estimating the differences and equalities ...
  • Tapera, Oscar; Dreyer, Greta; Nyakabau, Anna M; Kadzatsa, Webster; Stray-Pedersen, Babill; Hendricks, Stephen J H (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Cervical cancer treatment and care remains limited in Zimbabwe despite the growing burden of the disease among women. This study was aimed at investigating strategies to address barriers in ...
  • Falk, Anna; Heine, Vivi M.; Harwood, Adrian J.; Sullivan, Patrick F.; Peitz, Michael; Brüstle, Oliver; Shen, Sanbring; Sun, Yuh-Man; Glover, Joel; Posthuma, Daniëlle; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly ...