Browsing Institutt for klinisk medisin by Title
Now showing items 2013-2032 of 4694
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background The Lp(a) lipoprotein (Lp(a)) consists of the polymorphic glycoprotein apolipoprotein(a) (apo(a)), which is attached by a disulfide bond to apolipoprotein B (apoB). Apo(a), which has high homology ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Cysteine cathepsins are critical components of the adaptive immune system involved in the generation of epitopes for presentation on human leukocyte antigen (HLA) molecules and have been implicated in degradation of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Endothelial cells (EC) play a central role in inflammation. E-selectin and ICAM-1 expression are essential for leukocyte recruitment and are good markers of EC activation. Most studies of EC activation are done in vitro ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based ...
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(Doctoral thesis / Doktoravhandling, 2010)Cells are directed by signals in their microenvironment. Knowledge about this communication is necessary to understand both normal processes and cancer. This PhD thesis focuses on the human bone marrow microenvironment ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI–III) and C1q, thereby eliminating their destructive effector functions (constant region ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Expensive CD4 count and viral load tests have failed the intended objective of enabling access to HIV therapy in poor resource settings. It is imperative to develop simple, affordable and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...
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(Doctoral thesis / Doktoravhandling, 2007)Tissue engineering is a new treatment strategy available to patients with injuries and diseases. The goal is to rebuild or replace damaged or dead tissue. The means is stem cells or differentiated organ specific cells, ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Human telomerase reverse transcriptase (hTERT) is an active component of telomerase and responsible for its catalytic activity, associated with cell proliferation and differentiation. For the first time, the present study ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)Transforming growth factor (TGF)-β1 (encoded by TGFB1) is the prototypic member of the TGF-β family of 33 proteins that orchestrate embryogenesis, development and tissue homeostasis1,2. Following its discovery3, enormous ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)ATP-binding cassette (ABC) transporters are of major importance for the restricted access of toxins and drugs to the human body. At the body's barrier tissues like the blood–brain barrier, these transporters are highly ...
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(Doctoral thesis / Doktoravhandling, 2014)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Background Hydrodilatation of the glenohumeral joint is by several authors reported to improve shoulder pain and range of motion for patients with adhesive capsulitis. Procedures described often involve ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. The degradation ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Hyperchloremic metabolic acidosis of renal origin results from a defect in renal tubular acidification mechanism, and this tubular dysfunction can consist of an altered tubular proton secretion or bicarbonate reabsorption ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Objective To investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality. Results Of 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Hyperemesis gravidarum (HG) is a pregnancy condition characterised by severe nausea and vomiting. Previous studies have shown an association between HG and depressive symptoms during pregnancy, but little is known about ...
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(Doctoral thesis / Doktoravhandling, 2010)Hyperglycaemia develops in 20-40% of renal transplant recipients, and is associated with increased cardiovascular morbidity and mortality. It is often unclear, however, whether hyperglycaemia is already present before the ...